Journal ArticleDOI
A basophil-neuronal axis promotes itch
Fang Wang,Fang Wang,Anna M. Trier,Fengxian Li,Fengxian Li,Seonyoung Kim,Zhen Chen,Jiani N. Chai,Madison R. Mack,Stephanie A. Morrison,Jennifer D. Hamilton,Jinok Baek,Jinok Baek,Ting-Lin B. Yang,Aaron M. Ver Heul,Amy Z. Xu,Zili Xie,Xintong Dong,Masato Kubo,Hongzhen Hu,Chyi Song Hsieh,Xinzhong Dong,Qin Liu,David J. Margolis,Marius Ardeleanu,Mark J. Miller,Brian S. Kim +26 more
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TLDR
In this paper, the authors identify that a large proportion of patients with atopic dermatitis harbor allergen-specific immunoglobulin E (IgE) and exhibit a propensity for acute itch flares.About:
This article is published in Cell.The article was published on 2021-01-21. It has received 94 citations till now.read more
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Journal ArticleDOI
Th2 Modulation of Transient Receptor Potential Channels: An Unmet Therapeutic Intervention for Atopic Dermatitis.
Jianghui Meng,Jianghui Meng,Yanqing Li,Michael Fischer,Martin Steinhoff,Weiwei Chen,Jiafu Wang,Jiafu Wang +7 more
TL;DR: In this article, the effect of T helper-2 (Th2) response on TRP channels was investigated and it was shown that interrupting Th2-driven modulation of the channels will inhibit the transition from acute to chronic atopic dermatitis.
Journal ArticleDOI
IL-33 signaling in sensory neurons promotes dry skin itch.
Anna M. Trier,Madison R. Mack,Avery Fredman,Masato Tamari,Aaron M. Ver Heul,Yonghui Zhao,Changxiong J. Guo,Oshri Avraham,Zachary K. Ford,Landon K. Oetjen,Jing Feng,Carina Dehner,Dean W. Coble,Asima Badic,Satoru Joshita,Masato Kubo,Robert W. Gereau,Jennifer Alexander-Brett,Valeria Cavalli,Steve Davidson,Hongzhen Hu,Qin Liu,Brian S. Kim +22 more
TL;DR: In this paper, the IL-33 receptor (IL-33R) was found to be critical for the development of chronic itch in atopic dermatitis and chronic pruritus of unknown origin (CPUO).
Journal ArticleDOI
IL-33 signaling in sensory neurons promotes dry skin itch
TL;DR: In this paper , the IL-33 receptor (IL-33R) was found to be a predominant mediator of chronic itch in certain contexts, depending on the tissue microenvironment.
Journal ArticleDOI
Enteric neuroimmune interactions coordinate intestinal responses in health and disease.
TL;DR: In this paper, the authors discuss how the enteric nervous system (ENS) can regulate and be regulated by immune responses and how such interactions control whole tissue physiology, and address the requirements for the proper regeneration of the ENS and restoration of GI function following the resolution of infection.
Journal ArticleDOI
Enteric neuroimmune interactions coordinate intestinal responses in health and disease
TL;DR: In this article , the authors discuss how the enteric nervous system (ENS) can regulate and be regulated by immune responses and how such interactions control whole tissue physiology, and address the requirements for the proper regeneration of the ENS and restoration of GI function following the resolution of infection.
References
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Journal ArticleDOI
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Dmitry Usoskin,Alessandro Furlan,Saiful Islam,Hind Abdo,Peter Lönnerberg,Daohua Lou,Jens Hjerling-Leffler,Jesper Z. Haeggström,Olga Kharchenko,Peter V. Kharchenko,Sten Linnarsson,Patrik Ernfors +11 more
TL;DR: The results suggest that itching during inflammatory skin diseases such as atopic dermatitis is linked to a distinct itch-generating type, and demonstrate single-cell RNA-seq as an effective strategy for dissecting sensory responsive cells into distinct neuronal types.
Journal ArticleDOI
IgE and mast cells in allergic disease
Stephen J. Galli,Mindy Tsai +1 more
TL;DR: Findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest clinically as asthma and other allergic disorders are discussed.
Journal ArticleDOI
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Eric L. Simpson,Thomas Bieber,Emma Guttman-Yassky,Lisa A. Beck,Andrew Blauvelt,Michael J. Cork,Jonathan I. Silverberg,Mette Deleuran,Yoko Kataoka,Jean-Philippe Lacour,Külli Kingo,Margitta Worm,Margitta Worm,Yves Poulin,Andreas Wollenberg,Yuhwen Soo,Neil M.H. Graham,Gianluca Pirozzi,Bolanle Akinlade,Heribert Staudinger,Vera Mastey,Laurent Eckert,Abhijit Gadkari,Neil Stahl,George D. Yancopoulos,Marius Ardeleanu +25 more
TL;DR: Dupilumab improved the signs and symptoms of atopic dermatitis, including pruritus, symptoms of anxiety and depression, and quality of life, as compared with placebo in two phase 3 trials of identical design.
Journal ArticleDOI
Atopic dermatitis and the atopic march.
TL;DR: Preliminary prevention studies with oral antihistamines provide evidence that early intervention might slow the atopic march, which has a tremendously negative effect on the quality of life of patients as well as family.
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Landon K. Oetjen,Madison R. Mack,Jing Feng,Timothy M. Whelan,Haixia Niu,Changxiong J. Guo,Sisi Chen,Anna M. Trier,Amy Z. Xu,Shivani V. Tripathi,Jialie Luo,Xiaofei Gao,Lihua Yang,Samantha L. Hamilton,Peter L. Wang,Jonathan R. Brestoff,Richard Brasington,Andras Schaffer,Frank Brombacher,Chyi-Song Hsieh,Robert W. Gereau,Mark J. Miller,Zhou-Feng Chen,Hongzhen Hu,Steve Davidson,Qin Liu,Brian S. Kim +26 more