T
Tomas Hudlicky
Researcher at Brock University
Publications - 461
Citations - 11149
Tomas Hudlicky is an academic researcher from Brock University. The author has contributed to research in topics: Total synthesis & Toluene dioxygenase. The author has an hindex of 51, co-authored 460 publications receiving 10540 citations. Previous affiliations of Tomas Hudlicky include Procter & Gamble & University of Geneva.
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Use of cyclopropanes and their derivatives in organic synthesis
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Modern Methods of Monosaccharide Synthesis from Non-Carbohydrate Sources.
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Applications of biotransformations and biocatalysis to complexity generation in organic synthesis.
Tomas Hudlicky,Josephine W. Reed +1 more
TL;DR: This tutorial review provides a survey of syntheses in which an enzyme step contributed to generating downstream molecular complexity in the target, and provides a guide to the types of enzymatic transformations suitable for incorporation into synthetic schemes.
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Anionic approaches to the construction of cyclopentanoids
Tomas Hudlicky,John D. Price +1 more
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Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast
Yang Qu,Michael L. A. E. Easson,Jordan Froese,Razvan Simionescu,Tomas Hudlicky,Vincenzo De Luca +5 more
TL;DR: Bioinformatics and virus-induced gene silencing (VIGS)-guided gene discovery combined with biochemical enzyme assays show that tabersonine 3-oxygenase (T3O) and tabersonines 3-reductase ( T3R) are required to form 3-hydroxy-16-methoxy-2,3-dihydrotabersonine, an intermediate in the formation of anticancer drug precursor vindoline from tabersonin.