T
Tomas Hudlicky
Researcher at Brock University
Publications - 461
Citations - 11149
Tomas Hudlicky is an academic researcher from Brock University. The author has contributed to research in topics: Total synthesis & Toluene dioxygenase. The author has an hindex of 51, co-authored 460 publications receiving 10540 citations. Previous affiliations of Tomas Hudlicky include Procter & Gamble & University of Geneva.
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Chemoenzymatic Total Synthesis of Hydromorphone by an Oxidative Dearomatization/Intramolecular [4 + 2] Cycloaddition Sequence: A Second-Generation Approach
Lukas Rycek,John J. Hayward,Marwa Abdel Latif,James M. Tanko,Razvan Simionescu,Tomas Hudlicky +5 more
TL;DR: A second-generation approach to the synthesis of hydromorphone by oxidative dearomatization/Diels-Alder cycloaddition was investigated, and a formal synthesis of the natural enantiomer of hydROMorphone was completed.
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Synthesis of dienic acids. Application of arndt - eistert reaction to unsaturated diazoketones
Tomas Hudlicky,Jagdish P. Sheth +1 more
TL;DR: Different modes of decomposition of dienic diazoketones have been studied, leading to either formation of vinyl-cyclopropanes or Wolff-rearranged acids or esters as discussed by the authors.
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Chemoenzymatic and electrochemical oxidations in the synthesis of octahydroisoquinolines for conversion to morphine. Relative merits of radical vs. acid-catalyzed cyclizations
TL;DR: The second generation stereoselective synthesis of octahydroisoquinoline 3, a potential key intermediate for the projected synthesis of the natural enantiomer of morphine, has been accomplished in five steps from arene cis-diol 8.
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Nucleophilic substitution of protected β-bromoethyl cyclohexadiene-cis-diol as an alternative to direct microbial oxidation of β-functionalized phenethyl substrates
TL;DR: In this article, a nucleophilic substitution reaction using C-, N-, O- and S-based nucleophiles was performed on 5S, 6R, 1-(2-Bromoethyl)-5,6-(propane-2,2-diyldioxy)cyclohexa-1,3-diene 6.