T
Tomoko Nakanishi
Researcher at McGill University
Publications - 37
Citations - 788
Tomoko Nakanishi is an academic researcher from McGill University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 18 publications receiving 168 citations. Previous affiliations of Tomoko Nakanishi include Kyoto University.
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Failure to replicate the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19
Gundula Povysil,Guillaume Butler-Laporte,Ning Shang,Chen Weng,Atlas Khan,Manal Alaamery,Manal Alaamery,Tomoko Nakanishi,Sirui Zhou,Vincenzo Forgetta,Robert Eveleigh,Mathieu Bourgey,Naveed Aziz,Steven J.M. Jones,Bartha Maria Knoppers,Stephen W. Scherer,Lisa J. Strug,Pierre Lepage,Jiannis Ragoussis,Guillaume Bourque,Jahad Alghamdi,Nora Aljawini,Nora Aljawini,Nour Albes,Nour Albes,Hani M. Al-Afghani,Bader Alghamdi,Mansour Almutair,Ebrahim Mahmoud,Leen Abu Safie,Hadeel El Bardisy,Fawz S. Al Harthi,Abdulraheem Alshareef,Bandar A. Suliman,Saleh A. Alqahtani,Abdulaziz Almalik,May Alrashed,Salam Massadeh,Salam Massadeh,Vincent Mooser,Mark Lathrop,Yaseen Arabi,Yaseen Arabi,Hamdi Mbarek,Chadi Saad,Wadha Al-Muftah,Radja Badji,Asma Al Thani,Said I. Ismail,Ali G. Gharavi,Malak Abedalthagafi,J. Brent Richards,David Goldstein,Krzysztof Kiryluk +53 more
TL;DR: In this article, rare predicted loss-of-function (pLOF) variants across 13 candidate genes in TLR3- and IRF7-dependent type I IFN pathways explain up to 3.5% of severe COVID-19 cases.
Posted ContentDOI
Alternative splicing of OAS1 alters the risk for severe COVID-19
Jennifer E. Huffman,Guillaume Butler-Laporte,Atlas Khan,Theodore G. Drivas,Theodore G. Drivas,Gina M. Peloso,Gina M. Peloso,Tomoko Nakanishi,Anurag Verma,Krzysztof Kiryluk,J. Brent Richards,J. Brent Richards,Hugo Zeberg,Hugo Zeberg +13 more
TL;DR: In this paper, a splice variant of OAS1 was found in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry.
Posted ContentDOI
Vitamin D and Covid-19 Susceptibility and Severity: a Mendelian Randomization Study
Guillaume Butler-Laporte,Tomoko Nakanishi,Vincent Mooser,David R. Morrison,Tala Abdullah,Olumide Adeleye,Noor Mamlook,Nofar Kimchi,Zaman Afrasiabi,Nardin Rezk,Annarita Giliberti,Alessandra Renieri,Yiheng Chen,Sirui Zhou,Vincenzo Forgetta,J. Brent Richards +15 more
TL;DR: Findings do not support a protective role of increased 25OHD levels on Covid-19 outcomes and may suggest harm, and on-going supplementation trials should closely monitor for signals of harm.
Journal ArticleDOI
The effect of angiotensin-converting enzyme levels on Covid-19 susceptibility and severity: a Mendelian randomization study.
Guillaume Butler-Laporte,Tomoko Nakanishi,Vincent Mooser,Alessandra Renieri,Sara Amitrano,Sirui Zhou,Yiheng Chen,Vincenzo Forgetta,J. Brent Richards +8 more
TL;DR: The authors used Mendelian randomization to test whether decreased ACE levels increase susceptibility to SARS-CoV-2 infection or COVID-19 severity, while reducing potential bias from confounding and reverse causation in observational studies.
Journal ArticleDOI
Genetic Determinants of Antibody-Mediated Immune Responses to Infectious Diseases Agents: A Genome-Wide and HLA Association Study.
Guillaume Butler-Laporte,Devin Kreuzer,Tomoko Nakanishi,Tomoko Nakanishi,Adil Harroud,Vincenzo Forgetta,J. Brent Richards +6 more
TL;DR: Multiple genetic variants associated with antibody immune response to 13 infections are identified, many of which are biologically plausible therapeutic or vaccine targets and may help prioritize future research and drug development.