Y
Yiheng Chen
Researcher at McGill University
Publications - 21
Citations - 339
Yiheng Chen is an academic researcher from McGill University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 7 publications receiving 84 citations. Previous affiliations of Yiheng Chen include Jewish General Hospital.
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Journal ArticleDOI
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Sirui Zhou,Guillaume Butler-Laporte,Tomoko Nakanishi,David R. Morrison,Jonathan Afilalo,Marc Afilalo,Laetitia Laurent,Maik Pietzner,Nicola D. Kerrison,Kaiqiong Zhao,Elsa Brunet-Ratnasingham,Danielle Henry,Nofar Kimchi,Zaman Afrasiabi,Nardin Rezk,Meriem Bouab,Louis Petitjean,Charlotte Guzman,Xiaoqing Xue,Chris Tselios,Branka Vulesevic,Olumide Adeleye,Tala Abdullah,Noor Almamlouk,Yiheng Chen,Michaël Chassé,Madeleine Durand,Clare Paterson,Johan Normark,Robert Frithiof,Miklos Lipcsey,Michael Hultström,Celia M. T. Greenwood,Hugo Zeberg,Claudia Langenberg,Claudia Langenberg,Elin Thysell,Michael Pollak,Vincent Mooser,Vincenzo Forgetta,Daniel Kaufmann,J. Brent Richards +41 more
TL;DR: In this article, a two-sample Mendelian randomization (MR) study was conducted to identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding.
Journal ArticleDOI
Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study
Guillaume Butler-Laporte,Tomoko Nakanishi,Vincent Mooser,David R. Morrison,Tala Abdullah,Olumide Adeleye,Noor Mamlouk,Nofar Kimchi,Nofar Kimchi,Zaman Afrasiabi,Nardin Rezk,Annarita Giliberti,Alessandra Renieri,Yiheng Chen,Sirui Zhou,Vincenzo Forgetta,J. Brent Richards +16 more
TL;DR: In this paper, a 2-sample Mendelian randomization (MR) was used to assess evidence supporting a causal effect of circulating 25-hydroxy vitamin D (25OHD) levels on COVID-19 susceptibility and severity.
Journal ArticleDOI
Electrochemical Detection of a Few Copies of Unamplified SARS-CoV-2 Nucleic Acids by a Self-Actuated Molecular System
Daizong Ji,Mingquan Guo,Yungen Wu,Wentao Liu,Shiguo Luo,Xuejun Wang,Hua Kang,Yiheng Chen,Changhao Dai,De-Jun Kong,Hongwenjie Ma,Yunqi Liu,Dacheng Wei +12 more
TL;DR: A self-actuated molecular-electrochemical system that consists of a tentacle and a trunk modification on a graphene microelectrode that detects unamplified SARS-CoV-2 RNAs within 1 min down to 4 copies in 80 μL, 2–6 orders of magnitude lower than those of other electrochemical assays.
Journal ArticleDOI
Triple-Probe DNA Framework-Based Transistor for SARS-CoV-2 10-in-1 Pooled Testing
Yungen Wu,Daizong Ji,Changhao Dai,De-Jun Kong,Yiheng Chen,Liqian Wang,Mingquan Guo,Yunqi Liu,Dacheng Wei +8 more
TL;DR: A graphene field-effect transistor sensor modified with triple-probe tetrahedral DNA framework (TDF) dimers for 10-in-1 pooled testing of SARS-CoV-2 RNA that identifies all of the 14 positive cases in 30 nasopharyngeal swabs within an average diagnosis time of 74 s.
Posted ContentDOI
Circulating Proteins Influencing COVID-19 Susceptibility and Severity: a Mendelian Randomization Study
Sirui Zhou,Sirui Zhou,Guillaume Butler-Laporte,Guillaume Butler-Laporte,Tomoko Nakanishi,David R. Morrison,Jonathan Afilalo,Marc Afilalo,Laetitia Laurent,Maik Pietzner,Nicola D. Kerrison,Kaiqiong Zhao,Kaiqiong Zhao,Elsa Brunet-Ratnasingham,Danielle Henry,Nofar Kimchi,Zaman Afrasiabi,Nardin Rezk,Meriem Bouab,Charlotte Guzman,Louis Petitjean,Xiaoqing Xue,Chris Tselios,Branka Vulesevic,Olumide Adeleye,Tala Abdullah,Noor Almamlouk,Yiheng Chen,Madeleine Durand,Michaël Chassé,Johan Normark,Elin Thysell,Robert Frithiof,Miklos Lipcsey,Michael Hultström,Clare Paterson,Michael Pollak,Hugo Zeberg,Celia M. T. Greenwood,Celia M. T. Greenwood,Claudia Langenberg,Claudia Langenberg,Vincent Mooser,Vincenzo Forgetta,Daniel Kaufmann,Brent Richards +45 more
TL;DR: It was found that a standard deviation increase in OAS1 levels was associated with reduced COVID-19 death or ventilation, and available medicines, such as interferon-beta-1b, increase Oas1 and could be explored for their effect on CO VID-19 susceptibility and severity.