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Tomoko Nakanishi
Researcher at McGill University
Publications - 37
Citations - 788
Tomoko Nakanishi is an academic researcher from McGill University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 18 publications receiving 168 citations. Previous affiliations of Tomoko Nakanishi include Kyoto University.
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Journal ArticleDOI
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
Satoshi Yoshiji,Guillaume Butler-Laporte,Tianyuan Lu,Julian Daniel Sunday Willett,Chen-Yang Su,Tomoko Nakanishi,David R. Morrison,Yiheng Chen,Kevin Y. H. Liang,Michael Hultström,Yann Ilboudo,Zaman Afrasiabi,Shanshan Lan,N Duggan,Chantal DeLuca,Mitra Vaezi,Chris Tselios,Xiaoqing Xue,M. Bouab,Fang Shi,Lætitia Laurent,Hans Markus Münter,Marc Afilalo,Jonathan Afilalo,Vincent Mooser,Nicholas J. Timpson,Hugo Zeberg,Sirui Zhou,Vincenzo Forgetta,Yossi Farjoun,J. Brent Richards +30 more
TL;DR: In this paper , the authors identified circulating proteins mediating the effects of obesity on Coronavirus disease (COVID-19) severity in humans using Mendelian randomization and found that an s.d. increase in nephronectin (NPNT) was associated with increased odds of critically ill patients.
Journal ArticleDOI
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
Yiheng Chen,Tianyuan Lu,Ulrika Pettersson-Kymmer,Isobel D. Stewart,Guillaume Butler-Laporte,Tomoko Nakanishi,Agustin Cerani,Kevin Y. H. Liang,Satoshi Yoshiji,Julian Daniel Sunday Willett,Chen-Yang Su,Parminder Raina,Celia M. T. Greenwood,Yossi Farjoun,Vincenzo Forgetta,Claudia Langenberg,Sirui Zhou,Claes Ohlsson,J. Brent Richards +18 more
Journal ArticleDOI
Genetically increased circulating FUT3 level leads to reduced risk of Idiopathic Pulmonary Fibrosis: a Mendelian Randomisation Study.
Tomoko Nakanishi,Agustin Cerani,Vincenzo Forgetta,Sirui Zhou,Richard J. Allen,Olivia C. Leavy,Masaru Koido,Deborah Assayag,Deborah Assayag,R. Gisli Jenkins,R. Gisli Jenkins,Louise V. Wain,Louise V. Wain,Ivana V. Yang,G. Mark Lathrop,Paul J. Wolters,David A. Schwartz,J. Brent Richards +17 more
TL;DR: In this article, a two-sample Mendelian randomisation (MR) approach was used to identify candidate IPF-influencing circulating proteins, and the results showed that the levels of these circulating proteins influenced IPF susceptibility in the largest IPF GWAS (2668 cases and 8591 controls).
Posted ContentDOI
Circulating proteins to predict adverse COVID-19 outcomes
Chen-Yang Su Mr.,Chen-Yang Su Mr.,Sirui Zhou,Sirui Zhou,Edgar Gonzalez-Kozlova,Guillaume Butler-Laporte,Guillaume Butler-Laporte,Elsa Brunet-Ratnasingham,Tomoko Nakanishi,Wonseok Jeon,David R. Morrison,Laetitia Laurent,Joanthan Afilalo,Joanthan Afilalo,Marc Afilalo,Danielle Henry,Yiheng Chen,Yiheng Chen,Julia Carrasco-Zanini,Yossi Farjoun,Maik Pietzner,Maik Pietzner,Nofar Kimchi,Zaman Afrasiabi,Nardin Rezk,Meriem Bouab,Louis Petitjean,Charlotte Guzman,Xiaoqing Xue,Chris Tselios,Branka Vulesevic,Olumide Adeleye,Tala Abdullah,Noor Almamlouk,Yara Moussa,Chantal DeLuca,Naomi Duggan,Erwin Schurr,Nathalie Brassard,Madeleine Durand,Diane Marie Del Valle,Ryan Thompson,Mario A. Cedillo,Eric E. Schadt,Kai Nie,Nicole W. Simons,Konstantinos Mouskas,Nicolas Zaki,Manishkumar Patel,Hui Xie,Jocelyn Harris,Robert Marvin,Esther Cheng,Kevin Tuballes,Kimberly Argueta,Ieisha Scott,Celia M. T. Greenwood,Celia M. T. Greenwood,Clare Paterson,Michael A Hinterberg,Claudia Langenberg,Claudia Langenberg,Vincenzo Forgetta,Joelle Pineau,Vincent Mooser,Thomas U. Marron,Noam D. Beckmann,Ephraim Kenigsberg,Seunghee Kim-Schulze,Alexander W. Charney,Sacha Gnjatic,Daniel Kaufmann,Miriam Merad,J. Brent Richards +73 more
TL;DR: In this article, the authors measured 4,701 circulating human protein abundances in two independent cohorts totaling 986 individuals and trained prediction models including protein abundance and clinical risk factors to predict adverse COVID-19 outcomes.
Journal ArticleDOI
Colocalization of Gene Expression and DNA Methylation with Genetic Risk Variants Supports Functional Roles of MUC5B and DSP in Idiopathic Pulmonary Fibrosis.
Raphael Borie,Jonathan Cardwell,Iain R. Konigsberg,Camille M. Moore,Weiming Zhang,Sarah K. Sasse,Fabienne Gally,Evgenia Dobrinskikh,Avram D. Walts,Julia Powers,Janna Brancato,Mauricio Pardo Rojas,Paul J. Wolters,Kevin K. Brown,Timothy S. Blackwell,Tomoko Nakanishi,J. Brent Richards,Anthony N. Gerber,Tasha E. Fingerlin,Norman Sachs,Sara L. Pulit,Zachary Zappala,David A. Schwartz,Ivana V. Yang +23 more
TL;DR: The relationship of the common IPF genetic risk variants rs35705950 and rs2076295 with respective changes in MUC5B and DSP expression and methylation is established.