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Richard J. Allen
Researcher at University of Leicester
Publications - 49
Citations - 1820
Richard J. Allen is an academic researcher from University of Leicester. The author has contributed to research in topics: Medicine & Idiopathic pulmonary fibrosis. The author has an hindex of 11, co-authored 26 publications receiving 1045 citations. Previous affiliations of Richard J. Allen include University of York.
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Journal ArticleDOI
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank
Louise V. Wain,Nick Shrine,Suzanne Miller,Victoria E. Jackson,Ioanna Ntalla,María Soler Artigas,Charlotte K. Billington,Abdul Kader Kheirallah,Richard J. Allen,J. P. Cook,Kelly Probert,Ma'en Obeidat,Yohan Bossé,Ke Hao,Ke Hao,Dirkje S. Postma,Peter D. Paré,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Reedik Mägi,Evelin Mihailov,Eva Reinmaa,Erik Melén,Jared O'Connell,Jared O'Connell,Eleni Frangou,Olivier Delaneau,Olivier Delaneau,Colin Freeman,Desislava Petkova,Mark I. McCarthy,Mark I. McCarthy,Ian Sayers,Panos Deloukas,Panos Deloukas,Richard Hubbard,Ian D. Pavord,Anna Hansell,Anna Hansell,Neil C. Thomson,Eleftheria Zeggini,Andrew P. Morris,Jonathan Marchini,Jonathan Marchini,David P. Strachan,Martin D. Tobin,Martin D. Tobin,Ian P. Hall +48 more
TL;DR: By sampling from the extremes of the lung function distribution in UK Biobank, novel genetic causes of lung function and smoking behaviour are identified and substantial shared genetic architecture underlying airflow obstruction is shown across individuals, irrespective of smoking behaviour and other airway disease.
Journal ArticleDOI
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Nick Shrine,Anna L. Guyatt,A. Mesut Erzurumluoglu,Victoria E. Jackson,Victoria E. Jackson,Victoria E. Jackson,Brian D. Hobbs,Carl A. Melbourne,Chiara Batini,Katherine A. Fawcett,Kijoung Song,Phuwanat Sakornsakolpat,Phuwanat Sakornsakolpat,Xingnan Li,Ruth Boxall,Nicola F. Reeve,Ma'en Obeidat,Jing Hua Zhao,Matthias Wielscher,Stefan Weiss,Katherine A. Kentistou,James P. Cook,Benjamin B. Sun,Jian Zhou,Jennie Hui,Stefan Karrasch,Medea Imboden,Sarah E. Harris,Jonathan Marten,Stefan Enroth,Shona M. Kerr,Ida Surakka,Vitart,Terho Lehtimäki,Richard J. Allen,Per Bakke,Terri H. Beaty,Eugene R. Bleecker,Yohan Bossé,Corry-Anke Brandsma,Zhengming Chen,James D. Crapo,John Danesh,Dawn L. DeMeo,Frank Dudbridge,Ralf Ewert,Christian Gieger,Amund Gulsvik,Anna Hansell,Ke Hao,Joshua D. Hoffman,John E. Hokanson,Georg Homuth,Peter K. Joshi,Philippe Joubert,Claudia Langenberg,Liming Li,Kuang Lin,Lars Lind,Nicholas Locantore,Jian'an Luan,Anubha Mahajan,Joseph C. Maranville,Alison Catherine Murray,David C. Nickle,Richard Packer,Margaret M. Parker,Megan L. Paynton,David J. Porteous,Dmitry Prokopenko,Dandi Qiao,Rajesh Rawal,Heiko Runz,Ian Sayers,Don D. Sin,Blair H. Smith,María Soler Artigas,David Sparrow,Ruth Tal-Singer,Timmers Prhj,van den Berge M,John C. Whittaker,Prescott G. Woodruff,Laura M Yerges Armstrong,Olga G. Troyanskaya,Olli T. Raitakari,Mika Kähönen,Ozren Polasek,Ozren Polasek,Ulf Gyllensten,Igor Rudan,Ian J. Deary,Nicole Probst-Hensch,Nicole Probst-Hensch,Holger Schulz,Alan James,Alan James,James F. Wilson,Beate Stubbe,Eleftheria Zeggini,Marjo-Riitta Järvelin,Nicholas J. Wareham,Edwin K. Silverman,Caroline Hayward,Andrew P. Morris,Andrew P. Morris,Adam S. Butterworth,Robert A. Scott,Robin G Walters,Deborah A. Meyers,Michael H. Cho,David P. Strachan,Ian P. Hall,Tobin,Louise V. Wain,Louise V. Wain +115 more
TL;DR: In this paper, a genome-wide association study in 400,102 individuals of European ancestry was conducted to define 279 lung function signals, 139 of which are new and the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups.
Journal ArticleDOI
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Louise V. Wain,Louise V. Wain,Nick Shrine,María Soler Artigas,A. Mesut Erzurumluoglu,Boris Noyvert,Lara Bossini-Castillo,Ma'en Obeidat,Amanda P. Henry,Michael A. Portelli,Robert J. Hall,Charlotte K. Billington,Tracy L. Rimington,Anthony G. Fenech,Catherine John,Tineka Blake,Victoria E. Jackson,Richard J. Allen,Bram P. Prins,Archie Campbell,David J. Porteous,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Matthias Wielscher,Alan James,Alan James,Jennie Hui,Jennie Hui,Nicholas J. Wareham,Jing Hua Zhao,James F. Wilson,Peter K. Joshi,Beate Stubbe,Rajesh Rawal,Holger Schulz,Medea Imboden,Nicole Probst-Hensch,Stefan Karrasch,Christian Gieger,Ian J. Deary,Sarah E. Harris,Jonathan Marten,Igor Rudan,Stefan Enroth,Ulf Gyllensten,Shona M. Kerr,Ozren Polasek,Ozren Polasek,Mika Kähönen,Ida Surakka,Veronique Vitart,Caroline Hayward,Terho Lehtimäki,Olli T. Raitakari,David M. Evans,David M. Evans,A. John Henderson,Craig E. Pennell,Carol A. Wang,Peter D. Sly,Emily S. Wan,Robert Busch,Brian D. Hobbs,Augusto A. Litonjua,David Sparrow,Amund Gulsvik,Per Bakke,James D. Crapo,Terri H. Beaty,Nadia N. Hansel,Rasika A. Mathias,Ingo Ruczinski,Kathleen C. Barnes,Yohan Bossé,Philippe Joubert,Maarten van den Berge,Corry-Anke Brandsma,Peter D. Paré,Don D. Sin,David C. Nickle,Ke Hao,Omri Gottesman,Frederick E. Dewey,Shannon Bruse,David J. Carey,H. Lester Kirchner,Stefan Jonsson,Gudmar Thorleifsson,Ingileif Jonsdottir,Ingileif Jonsdottir,Thorarinn Gislason,Kari Stefansson,Kari Stefansson,Claudia Schurmann,Girish N. Nadkarni,Erwin P. Bottinger,Ruth J. F. Loos,Robin G. Walters,Zhengming Chen,Iona Y Millwood,Julien Vaucher,Om P Kurmi,Liming Li,Liming Li,Anna Hansell,Christopher E. Brightling,Christopher E. Brightling,Eleftheria Zeggini,Michael H. Cho,Edwin K. Silverman,Ian Sayers,Gosia Trynka,Andrew P. Morris,David P. Strachan,Ian P. Hall,Martin D. Tobin,Martin D. Tobin +116 more
TL;DR: In this article, a genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and they observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest GA risk score deciles in UK Biobank.
Journal ArticleDOI
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Richard J. Allen,Joanne Porte,Rebecca Braybrooke,Carlos Flores,Tasha E. Fingerlin,Justin M. Oldham,Beatriz Guillen-Guio,Shwu-Fan Ma,Tsukasa Okamoto,Alison E. John,Ma'en Obeidat,Ivana V. Yang,Amanda P. Henry,Richard Hubbard,Vidya Navaratnam,Gauri Saini,Norma Thompson,Helen Booth,Simon P. Hart,Michael Hill,Nik Hirani,Toby M. Maher,Robin J. McAnulty,Ann B. Millar,Philip L. Molyneaux,Helen Parfrey,Doris M Rassl,Moira K. B. Whyte,William A. Fahy,Richard P. Marshall,Eunice Oballa,Yohan Bossé,David C. Nickle,Don D. Sin,Wim Timens,Nick Shrine,Ian Sayers,Ian P. Hall,Imre Noth,David A. Schwartz,Martin D. Tobin,Louise V. Wain,Louise V. Wain,R. Gisli Jenkins +43 more
TL;DR: The identification of AKAP13 as a susceptibility gene for IPF increases the prospect of successfully targeting RhoA pathway inhibitors in patients with IPF.
Journal ArticleDOI
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.
Richard J. Allen,Beatriz Guillen-Guio,Justin M. Oldham,Shwu-Fan Ma,Amy Dressen,Megan L. Paynton,Luke M. Kraven,Ma'en Obeidat,Xuan Li,Michael Ng,Rebecca Braybrooke,Maria Molina-Molina,Maria Molina-Molina,Brian D. Hobbs,Rachel K. Putman,Phuwanat Sakornsakolpat,Helen Booth,William A. Fahy,Simon P. Hart,Michael Hill,Nik Hirani,Richard Hubbard,Robin J. McAnulty,Ann B. Millar,Vidyia Navaratnam,Eunice Oballa,Helen Parfrey,Gauri Saini,Moira K. B. Whyte,Yingze Zhang,Naftali Kaminski,Ayodeji Adegunsoye,Mary E. Strek,Margaret Neighbors,Xuting R. Sheng,Gunnar Gudmundsson,Vilmundur Gudnason,Hiroto Hatabu,David J. Lederer,Ani Manichaikul,John D. Newell,John D. Newell,George T. O'Connor,George T. O'Connor,Victor E. Ortega,Hanfei Xu,Tasha E. Fingerlin,Yohan Bossé,Ke Hao,Philippe Joubert,David C. Nickle,Don D. Sin,Wim Timens,Wim Timens,Dominic Furniss,Andrew P. Morris,Andrew P. Morris,Krina T. Zondervan,Ian P. Hall,Ian P. Hall,Ian Sayers,Ian Sayers,Martin D. Tobin,Martin D. Tobin,Toby M. Maher,Toby M. Maher,Michael H. Cho,Gary M. Hunninghake,David A. Schwartz,Brian L. Yaspan,Philip L. Molyneaux,Philip L. Molyneaux,Carlos Flores,Imre Noth,R. Gisli Jenkins,R. Gisli Jenkins,Louise V. Wain,Louise V. Wain +77 more
TL;DR: The observation that decreased DEPTOR expression associates with increased susceptibility to IPF supports recent studies demonstrating the importance of mTOR signaling in lung fibrosis, and new signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility.