L
Laetitia Laurent
Researcher at McGill University
Publications - 8
Citations - 706
Laetitia Laurent is an academic researcher from McGill University. The author has contributed to research in topics: Bone fracture & Osteoporosis. The author has an hindex of 5, co-authored 8 publications receiving 359 citations. Previous affiliations of Laetitia Laurent include Jewish General Hospital.
Papers
More filters
Journal ArticleDOI
An atlas of genetic influences on osteoporosis in humans and mice
John A. Morris,John P. Kemp,John P. Kemp,Scott E. Youlten,Laetitia Laurent,John G. Logan,Ryan C. Chai,Nicholas A. Vulpescu,Vincenzo Forgetta,Aaron Kleinman,Sindhu T. Mohanty,C. Marcelo Sergio,Julian M.W. Quinn,Loan Nguyen-Yamamoto,Aimee Lee Luco,Jinchu Vijay,Marie-Michelle Simon,Albena Pramatarova,Carolina Medina-Gomez,Katerina Trajanoska,Elena J. Ghirardello,Natalie C. Butterfield,Katharine F. Curry,Victoria D. Leitch,Penny C. Sparkes,Anne-Tounsia Adoum,Naila S. Mannan,Davide Komla-Ebri,Andrea S. Pollard,Hannah F. Dewhurst,Thomas A D Hassall,Michael-John G. Beltejar,Douglas J. Adams,Suzanne M. Vaillancourt,Stephen Kaptoge,Paul A. Baldock,Cyrus Cooper,Cyrus Cooper,Cyrus Cooper,Jonathan Reeve,Evangelia E. Ntzani,Evangelia E. Ntzani,Evangelos Evangelou,Evangelos Evangelou,Claes Ohlsson,David Karasik,Fernando Rivadeneira,Douglas P. Kiel,Jonathan H Tobias,Celia L Gregson,Nicholas C. Harvey,Nicholas C. Harvey,Elin Grundberg,Elin Grundberg,David Goltzman,David J. Adams,Christopher J. Lelliott,David A. Hinds,Cheryl L. Ackert-Bicknell,Yi-Hsiang Hsu,Matthew T. Maurano,Peter I. Croucher,Graham R. Williams,J. H. Duncan Bassett,David M. Evans,David M. Evans,J. Brent Richards +66 more
TL;DR: This genetic atlas provides evidence linking associated SNPs to causal genes, offers new insight into osteoporosis pathophysiology, and highlights opportunities for drug development.
Journal ArticleDOI
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Sirui Zhou,Guillaume Butler-Laporte,Tomoko Nakanishi,David R. Morrison,Jonathan Afilalo,Marc Afilalo,Laetitia Laurent,Maik Pietzner,Nicola D. Kerrison,Kaiqiong Zhao,Elsa Brunet-Ratnasingham,Danielle Henry,Nofar Kimchi,Zaman Afrasiabi,Nardin Rezk,Meriem Bouab,Louis Petitjean,Charlotte Guzman,Xiaoqing Xue,Chris Tselios,Branka Vulesevic,Olumide Adeleye,Tala Abdullah,Noor Almamlouk,Yiheng Chen,Michaël Chassé,Madeleine Durand,Clare Paterson,Johan Normark,Robert Frithiof,Miklos Lipcsey,Michael Hultström,Celia M. T. Greenwood,Hugo Zeberg,Claudia Langenberg,Claudia Langenberg,Elin Thysell,Michael Pollak,Vincent Mooser,Vincenzo Forgetta,Daniel Kaufmann,J. Brent Richards +41 more
TL;DR: In this article, a two-sample Mendelian randomization (MR) study was conducted to identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding.
Posted ContentDOI
Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality
Elsa Brunet-Ratnasingham,Sai Priya Anand,Sai Priya Anand,Pierre Gantner,Gaël Moquin-Beaudry,Alina Dyachenko,Nathalie Brassard,Guillaume Beaudoin-Bussières,Amélie Pagliuzza,Romain Gasser,Mehdi Benlarbi,Floriane Point,Jérémie Prévost,Annemarie Laumaea,Julia Nießl,Manon Nayrac,Gérémy Sannier,Marianne Boutin,Jade Descôteaux-Dinelle,Gabrielle Gendron,Catherine Orban,Guillaume Butler-Laporte,Guillaume Butler-Laporte,David R. Morrison,Sirui Zhou,Sirui Zhou,Tomoko Nakanishi,Laetitia Laurent,Jonathan Richard,Mathieu Dubé,Rémi Fromentin,Rose-Marie Rébillard,Nathalie Arbour,Alexandre Prat,Catherine Larochelle,Madeleine Durand,Brent Richards,Michaël Chassé,Martine Tétreault,Nicolas Chomont,Andrés Finzi,Daniel Kaufmann +41 more
TL;DR: In this paper, the authors performed an immunovirological assessment (SARS-CoV-2 viral RNA, cytokines and tissue injury markers, antibody responses) on plasma samples collected from 144 hospitalised COVID-19 patients 11 days after symptom onset and used to test models predicting mortality within 60 days of symptom onset.
Journal ArticleDOI
Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality
Elsa Brunet-Ratnasingham,Sai Priya Anand,Sai Priya Anand,Pierre Gantner,Alina Dyachenko,Gaël Moquin-Beaudry,Nathalie Brassard,Guillaume Beaudoin-Bussières,Amélie Pagliuzza,Romain Gasser,Mehdi Benlarbi,Floriane Point,Jérémie Prévost,Annemarie Laumaea,Julia Niessl,Manon Nayrac,Gérémy Sannier,Catherine Orban,Marc Messier-Peet,Guillaume Butler-Laporte,David R. Morrison,Sirui Zhou,Tomoko Nakanishi,Marianne Boutin,Jade Descôteaux-Dinelle,Gabrielle Gendron-Lepage,Guillaume Goyette,Catherine Bourassa,Halima Medjahed,Laetitia Laurent,Rose-Marie Rébillard,Jonathan Richard,Mathieu Dubé,Rémi Fromentin,Nathalie Arbour,Alexandre Prat,Catherine Larochelle,Madeleine Durand,J. Brent Richards,Michaël Chassé,Martine Tétreault,Nicolas Chomont,Andrés Finzi,Andrés Finzi,Daniel Kaufmann +44 more
TL;DR: The authors identified early predictors of mortality within 60 days of symptom onset (DSO) within COVID-19 management, identifying patients evolving toward death remains challenging, despite advances in COVID19 management.
Posted ContentDOI
Circulating Proteins Influencing COVID-19 Susceptibility and Severity: a Mendelian Randomization Study
Sirui Zhou,Sirui Zhou,Guillaume Butler-Laporte,Guillaume Butler-Laporte,Tomoko Nakanishi,David R. Morrison,Jonathan Afilalo,Marc Afilalo,Laetitia Laurent,Maik Pietzner,Nicola D. Kerrison,Kaiqiong Zhao,Kaiqiong Zhao,Elsa Brunet-Ratnasingham,Danielle Henry,Nofar Kimchi,Zaman Afrasiabi,Nardin Rezk,Meriem Bouab,Charlotte Guzman,Louis Petitjean,Xiaoqing Xue,Chris Tselios,Branka Vulesevic,Olumide Adeleye,Tala Abdullah,Noor Almamlouk,Yiheng Chen,Madeleine Durand,Michaël Chassé,Johan Normark,Elin Thysell,Robert Frithiof,Miklos Lipcsey,Michael Hultström,Clare Paterson,Michael Pollak,Hugo Zeberg,Celia M. T. Greenwood,Celia M. T. Greenwood,Claudia Langenberg,Claudia Langenberg,Vincent Mooser,Vincenzo Forgetta,Daniel Kaufmann,Brent Richards +45 more
TL;DR: It was found that a standard deviation increase in OAS1 levels was associated with reduced COVID-19 death or ventilation, and available medicines, such as interferon-beta-1b, increase Oas1 and could be explored for their effect on CO VID-19 susceptibility and severity.