T
Tony Pawson
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 27
Citations - 3105
Tony Pawson is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Phosphorylation & Tyrosine kinase. The author has an hindex of 14, co-authored 27 publications receiving 2476 citations. Previous affiliations of Tony Pawson include Mount Sinai Hospital, Toronto & Institute of Cancer Research.
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Journal ArticleDOI
Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
Timothy J. Nott,Timothy J. Nott,Evangelia Petsalaki,Patrick Farber,Dylan Jervis,Eden Fussner,Anne Plochowietz,Timothy D. Craggs,David P. Bazett-Jones,Tony Pawson,Julie D. Forman-Kay,Andrew Baldwin +11 more
TL;DR: It is demonstrated that the disordered tails of Ddx4, a primary constituent of nuage or germ granules, form phase-separated organelles both in live cells and in vitro, and proposed that phase separation of disordered proteins containing weakly interacting blocks is a general mechanism for forming regulated, membraneless organlles.
Journal ArticleDOI
NetworKIN: a resource for exploring cellular phosphorylation networks.
Rune Linding,Lars Juhl Jensen,Adrian Pasculescu,Marina Olhovsky,Karen Colwill,Peer Bork,Michael B. Yaffe,Tony Pawson +7 more
TL;DR: How NetworKIN can be used for both global and targeted molecular studies is described, including how the resource offers insight into phosphorylation-modulated interaction networks.
Journal ArticleDOI
Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition
Jean-Philippe Lambert,Gordana Ivosev,Amber L. Couzens,Brett Larsen,Mikko Taipale,Zhen-Yuan Lin,Quan Zhong,Susan Lindquist,Susan Lindquist,Marc Vidal,Ruedi Aebersold,Ruedi Aebersold,Tony Pawson,Tony Pawson,Ron Bonner,Stephen A. Tate,Anne-Claude Gingras,Anne-Claude Gingras +17 more
TL;DR: It is shown that AP-SWATH is a robust label-free approach to characterize changes in protein-protein interactions imparted by the HSP90 inhibitor NVP-AUY922 or melanoma-associated mutations in the human kinase CDK4 and proposed a scalable pipeline for systems biology studies.
Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition
Jean-Philippe Lambert,Gordana Ivosev,Amber L. Couzens,Brett Larsen,Mikko Taipale,Zhen-Yuan Lin,Quan Zhong,Susan Lindquist,Susan Lindquist,Marc Vidal,Ruedi Aebersold,Ruedi Aebersold,Tony Pawson,Tony Pawson,Ron Bonner,Stephen A. Tate,Anne-Claude Gingras,Anne-Claude Gingras +17 more
TL;DR: In this article, changes to protein interactomes as a result of mutations to the bait protein or addition of a pharmacological inhibitor are robustly monitored with affinity purification coupled with data-independent acquisition-based mass spectrometry and an automated data analysis pipeline.
Journal ArticleDOI
A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint
Marcel A. T. M. van Vugt,Alexandra K. Gardino,Rune Linding,Gerard J. Ostheimer,H. Christian Reinhardt,Shao En Ong,Chris Soon Heng Tan,Hua Miao,Susan Keezer,Jeijin Li,Tony Pawson,Timothy A. Lewis,Steven A. Carr,Stephen J. Smerdon,Thijn R. Brummelkamp,Michael B. Yaffe +15 more
TL;DR: A combined computational and biochemical approach reveals how mitotic kinases allow cell division to proceed in the presence of DNA damage.