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Chris Soon Heng Tan
Researcher at Southern University of Science and Technology
Publications - 32
Citations - 1766
Chris Soon Heng Tan is an academic researcher from Southern University of Science and Technology. The author has contributed to research in topics: Phosphorylation & Chemistry. The author has an hindex of 17, co-authored 25 publications receiving 1487 citations. Previous affiliations of Chris Soon Heng Tan include Austrian Academy of Sciences & Mount Sinai Hospital, Toronto.
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Journal ArticleDOI
Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling
Mike Clarke,Amanda J. Lohan,Bernard A. Liu,Ilias Lagkouvardos,Scott William Roy,Nikhat Zafar,Claire Bertelli,Christina Schilde,Arash Kianianmomeni,Thomas R. Bürglin,Christian Frech,Bernard Turcotte,Klaus O. Kopec,John M. Synnott,Caleb Choo,Ivan A. Paponov,Aliza Finkler,Chris Soon Heng Tan,Andrew P. Hutchins,Thomas Weinmeier,Thomas Rattei,Jeffery Sc Chu,Gregory Gimenez,Manuel Irimia,Daniel J. Rigden,David A. Fitzpatrick,Jacob Lorenzo-Morales,Alex Bateman,Cheng-Hsun Chiu,Petrus Tang,Peter Hegemann,Hillel Fromm,Didier Raoult,Gilbert Greub,Diego Miranda-Saavedra,Nansheng Chen,Piers Nash,Michael L. Ginger,Matthias Horn,Pauline Schaap,Lis Caler,Brendan J. Loftus +41 more
TL;DR: In this paper, the authors present an analysis of a whole genome assembly of Acanthamoeba castellanii (Ac) the first representative from a solitary freeliving amoebozoan.
Journal ArticleDOI
A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint
Marcel A. T. M. van Vugt,Alexandra K. Gardino,Rune Linding,Gerard J. Ostheimer,H. Christian Reinhardt,Shao En Ong,Chris Soon Heng Tan,Hua Miao,Susan Keezer,Jeijin Li,Tony Pawson,Timothy A. Lewis,Steven A. Carr,Stephen J. Smerdon,Thijn R. Brummelkamp,Michael B. Yaffe +15 more
TL;DR: A combined computational and biochemical approach reveals how mitotic kinases allow cell division to proceed in the presence of DNA damage.
Journal ArticleDOI
Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases.
Chris Soon Heng Tan,Bernd Bodenmiller,Adrian Pasculescu,Marko Jovanovic,Michael O. Hengartner,Claus Jørgensen,Gary D. Bader,Gary D. Bader,Ruedi Aebersold,Tony Pawson,Tony Pawson,Rune Linding +11 more
TL;DR: It is revealed that multiple complex diseases seem to converge within the conserved networks, suggesting that disease development might rely on common molecular networks and that conserved regulatory networks may be involved in different diseases.
Supplementary Materials for Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases
Journal ArticleDOI
Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling
Kilian Huber,Karin M Olek,André C. Müller,Chris Soon Heng Tan,Keiryn L. Bennett,Jacques Colinge,Giulio Superti-Furga,Giulio Superti-Furga +7 more
TL;DR: Thermal stabilization of proteins after ligand binding provides an efficient means to assess the binding of small molecules to proteins and in combination with quantitative mass spectrometry allows for the systematic survey of protein engagement by cellular metabolites and drugs.