T
Tsuyoshi Hirota
Researcher at Nagoya University
Publications - 67
Citations - 4286
Tsuyoshi Hirota is an academic researcher from Nagoya University. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 26, co-authored 58 publications receiving 3569 citations. Previous affiliations of Tsuyoshi Hirota include University of California, San Diego & National Presto Industries.
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Journal ArticleDOI
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
Eric E. Zhang,Yi Liu,Yi Liu,Renaud Dentin,Pagkapol Y. Pongsawakul,Andrew C. Liu,Andrew C. Liu,Andrew C. Liu,Tsuyoshi Hirota,Tsuyoshi Hirota,Dmitri A. Nusinow,Xiujie Sun,Severine Landais,Yuzo Kodama,David A. Brenner,Marc Montminy,Steve A. Kay +16 more
TL;DR: It is shown that Creb activity during fasting is modulated by Cry1 and Cry2, which are rhythmically expressed in the liver, which suggest that compounds that enhance cryptochrome activity may provide therapeutic benefit to individuals with type 2 diabetes.
Journal ArticleDOI
Identification of small molecule activators of cryptochrome.
Tsuyoshi Hirota,Jae Wook Lee,Peter C. St. John,Mariko Sawa,Keiko Iwaisako,Takako Noguchi,Pagkapol Y. Pongsawakul,Tim Sonntag,David K. Welsh,David K. Welsh,David A. Brenner,Francis J. Doyle,Peter G. Schultz,Steve A. Kay +13 more
TL;DR: KL001 provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes, and revealed that CRY1 and CRY2 share a similar functional role in the period regulation.
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A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells
Eric E. Zhang,Eric E. Zhang,Andrew C. Liu,Andrew C. Liu,Tsuyoshi Hirota,Tsuyoshi Hirota,Loren Miraglia,Genevieve Welch,Pagkapol Y. Pongsawakul,Xianzhong Liu,Ann Atwood,Jon W. Huss,Jeff Janes,Andrew I. Su,John B. Hogenesch,Steve A. Kay +15 more
TL;DR: The clock is interconnected with many aspects of cellular function and overrepresented genes are overrepresented for components of insulin and hedgehog signaling, the cell cycle, and the folate metabolism.
Journal ArticleDOI
Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured rat-1 fibroblasts
Tsuyoshi Hirota,Toshiyuki Okano,Koichi Kokame,Hiroko Shirotani-Ikejima,Toshiyuki Miyata,Yoshitaka Fukada +5 more
TL;DR: A novel mode of peripheral clock resetting by external glucose, a major food metabolite, is illustrated, suggesting that the transcriptional regulators mediate the glucose-induced down-regulation of Per1 andPer2 expression.
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A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β
TL;DR: The development of a high-throughput circadian functional assay system that consists of luminescent reporter cells, screening automation, and a data analysis pipeline is reported, finding that small molecule inhibitors of glycogen synthase kinase 3 (GSK-3) consistently caused a strong short period phenotype in contrast to the well-known period lengthening by lithium.