T
Tyler S. Harmon
Researcher at Max Planck Society
Publications - 21
Citations - 2863
Tyler S. Harmon is an academic researcher from Max Planck Society. The author has contributed to research in topics: Intrinsically disordered proteins & Alpha helix. The author has an hindex of 13, co-authored 21 publications receiving 1850 citations. Previous affiliations of Tyler S. Harmon include Washington University in St. Louis.
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Journal ArticleDOI
Coexisting Liquid Phases Underlie Nucleolar Subcompartments
Marina Feric,Nilesh Vaidya,Tyler S. Harmon,Diana M. Mitrea,Lian Zhu,Tiffany M. Richardson,Richard W. Kriwacki,Rohit V. Pappu,Clifford P. Brangwynne +8 more
TL;DR: It is shown that subcompartments within the nucleolus represent distinct, coexisting liquid phases that may facilitate sequential RNA processing reactions in a variety of RNP bodies, and suggested that phase separation can give rise to multilayered liquids.
Journal ArticleDOI
Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins.
TL;DR: In this article, the physical properties of disordered linkers were used to determine the extent to which gelation of linear multivalent proteins is driven by phase separation, which is the biologically preferred mechanism for forming membraneless bodies.
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Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution
Jingyi Fei,Mahdieh Jadaliha,Tyler S. Harmon,Isaac T. S. Li,Boyang Hua,Qinyu Hao,Alex S. Holehouse,Matthew A Reyer,Qinyu Sun,Susan M. Freier,Rohit V. Pappu,Kannanganattu V. Prasanth,Taekjip Ha +12 more
TL;DR: Multi-color structured illumination microscopy imaging studies reveal a multilayer organization of nuclear speckles due to the interplay between favorable sequence-encoded intermolecular interactions of speckle-resident proteins and RNAs.
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Phase separation provides a mechanism to reduce noise in cells
Adam Klosin,F Oltsch,Tyler S. Harmon,Alf Honigmann,Alf Honigmann,Frank Jülicher,Frank Jülicher,Anthony A. Hyman,Anthony A. Hyman,Christoph Zechner,Christoph Zechner +10 more
TL;DR: A physical model is used that links noise in protein concentration to theory of phase separation to show that liquid droplets can effectively reduce noise and provide experimental support for noise reduction by phase separation using engineered proteins that form liquid-like compartments in mammalian cells.
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Injectable tissue integrating networks from recombinant polypeptides with tunable order
Stefan Roberts,Tyler S. Harmon,Jeffrey L. Schaal,Vincent N. Miao,Kan Jonathan Li,Andrew Hunt,Yi Wen,Terrence G. Oas,Joel H. Collier,Rohit V. Pappu,Ashutosh Chilkoti +10 more
TL;DR: A set of partially ordered polypeptides is created to study emergent hierarchical structures by precisely encoding nanoscale order–disorder interactions and it is shown that hysteresis arises from physical crosslinking due to mesoscale phase separation of ordered and disordered domains.