U
Ulrich T. Hopt
Researcher at University of Freiburg
Publications - 349
Citations - 11279
Ulrich T. Hopt is an academic researcher from University of Freiburg. The author has contributed to research in topics: Pancreatitis & Pancreas. The author has an hindex of 50, co-authored 347 publications receiving 10112 citations. Previous affiliations of Ulrich T. Hopt include University Medical Center Freiburg.
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Journal ArticleDOI
A new liposomal formulation of Gemcitabine is active in an orthotopic mouse model of pancreatic cancer accessible to bioluminescence imaging.
C. Bornmann,Ralph Graeser,Norbert Esser,Vittorio Ziroli,Peter Jantscheff,Tobias Keck,Clemens Unger,Ulrich T. Hopt,Ulrich Adam,C. Schaechtele,Ulrich Massing,E. von Dobschuetz +11 more
TL;DR: A liposomal formulation of Gemcitabine, GemLip, shows promising antitumoral activity on MIA PaCa-2 cells growing orthotopically in nude mice, and Surprisingly, empty liposomes attenuate the spread of metastases similar to Gem citabine and GemLips.
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Subcutaneous Redon drains do not reduce the incidence of surgical site infections after laparotomy. A randomized controlled trial on 200 patients
TL;DR: This is the first systematic randomized evaluation in patients undergoing laparotomy in visceral surgery to clarify whether widely used subcutaneous drains (Redon) affect wound infection as the primary outcome measure and could not demonstrate a reduction of SSI by the use of Redon drains.
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Short- and long-term results of duodenum preservation versus resection for the management of chronic pancreatitis: a prospective, randomized study.
Tobias Keck,Ulrich Adam,Frank Makowiec,Hartwig Riediger,Ulrich F. Wellner,D. Tittelbach-Helmrich,Ulrich T. Hopt +6 more
TL;DR: Both types of pancreatic head resections are equally effective in pain relief and eventual quality of life after long-term follow-up (>5 years) without differences in endocrine or exocrine function.
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Comprehensive analysis of the α‐fetoprotein‐specific CD8+ T cell responses in patients with hepatocellular carcinoma
Robert Thimme,Michaela Neagu,Tobias Boettler,Christoph Neumann-Haefelin,Nadine Kersting,Michael Geissler,Frank Makowiec,Robert Obermaier,Ulrich T. Hopt,Hubert E. Blum,Hans Christian Spangenberg +10 more
TL;DR: In patients with HCC, a high frequency of AFP‐specific CD8+ T cells directed against different epitopes suggest that AFP has a strong and broad immunogenicity, but also demonstrates a diversity of immune responses that may be needed for protection.
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Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma.
Ilona Kohler,Peter Bronsert,Sylvia Timme,Martin Werner,Martin Werner,Thomas Brabletz,Thomas Brabletz,Ulrich T. Hopt,Oliver Schilling,Dirk Bausch,Tobias Keck,Ulrich F. Wellner +11 more
TL;DR: Experimental data suggest an important role of epithelial‐mesenchymal transition (EMT) in invasion and metastasis of PDAC and biological and prognostic implications of EMT and tumor budding in PDAC of the pancreatic head are suggested.