U
Umberto D'Alessandro
Researcher at University of London
Publications - 289
Citations - 13619
Umberto D'Alessandro is an academic researcher from University of London. The author has contributed to research in topics: Malaria & Population. The author has an hindex of 58, co-authored 278 publications receiving 11996 citations. Previous affiliations of Umberto D'Alessandro include Medical Research Council & University of Antwerp.
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Journal ArticleDOI
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
Jane Achan,Ambrose Talisuna,Annette Erhart,Adoke Yeka,James K Tibenderana,Frederick N. Baliraine,Philip J. Rosenthal,Umberto D'Alessandro +7 more
TL;DR: In pregnancy, quinine continues to play a critical role in the management of malaria, especially in the first trimester, and it will remain a mainstay of treatment until safer alternatives become available.
Journal ArticleDOI
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.
Selidji T Agnandji,Selidji T Agnandji,Bertrand Lell,Bertrand Lell,José Francisco Fernandes,José Francisco Fernandes,Béatrice Peggy Abossolo,Béatrice Peggy Abossolo,Barbara Gaelle Nfono Ondo Methogo,Barbara Gaelle Nfono Ondo Methogo,Anita Lumeka Kabwende,Anita Lumeka Kabwende,Ayola A. Adegnika,Ayola A. Adegnika,Benjamin Mordmüller,Benjamin Mordmüller,Saadou Issifou,Saadou Issifou,Peter G. Kremsner,Peter G. Kremsner,Jahit Sacarlal,Pedro Aide,Miguel Lanaspa,John J. Aponte,Sonia Machevo,Sozinho Acácio,Helder Bulo,Betuel Sigaúque,Eusebio Macete,Pedro L. Alonso,Salim Abdulla,Salim Abdulla,Nahya Salim,Nahya Salim,Rose Minja,Rose Minja,Maxmillian Mpina,Maxmillian Mpina,Saumu Ahmed,Saumu Ahmed,Ali Ali,Ali Ali,Ali Mtoro,Ali Mtoro,Ali Hamad,Ali Hamad,Paul Mutani,Paul Mutani,Marcel Tanner,Marcel Tanner,Halidou Tinto,Umberto D'Alessandro,Hermann Sorgho,Innocent Valea,Biebo Bihoun,Issa Guiraud,Berenger Kaboré,Olivier Sombié,Robert T. Guiguemdé,Jean-Bosco Ouédraogo,Mary J. Hamel,Simon Kariuki,Martina Oneko,Chris Odero,Kephas Otieno,Norbert Awino,Meredith McMorrow,Vincent Muturi-Kioi,Kayla F. Laserson,Laurence Slutsker,Walter Otieno,Lucas Otieno,Nekoye Otsyula,Stacey M. O. Gondi,Allan Otieno,Victorine Owira,Esther Oguk,George Odongo,Jon Ben Woods,Bernhards Ogutu,Patricia Njuguna,Roma Chilengi,Pauline Akoo,Christine Kerubo,Charity Maingi,Trudie Lang,Ally Olotu,Philip Bejon,Kevin Marsh,Gabriel Mwambingu,Seth Owusu-Agyei,Kwaku Poku Asante,Kingsley Osei-Kwakye,Owusu Boahen,David Dosoo,Isaac Asante,George Adjei,Evans Kwara,Daniel Chandramohan,Brian Greenwood,John Lusingu,John Lusingu,John Lusingu,Samwel Gesase,Samwel Gesase,Samwel Gesase,Anangisye Malabeja,Anangisye Malabeja,Anangisye Malabeja,Omari Abdul,Omari Abdul,Omari Abdul,Coline Mahende,Coline Mahende,Coline Mahende,Edwin Liheluka,Edwin Liheluka,Edwin Liheluka,Lincoln Malle,Lincoln Malle,Lincoln Malle,M.M. Lemnge,M.M. Lemnge,M.M. Lemnge,Thor G. Theander,Thor G. Theander,Thor G. Theander,Chris Drakeley,Chris Drakeley,Chris Drakeley,Daniel Ansong,Tsiri Agbenyega,Samuel Adjei,Harry Owusu Boateng,Theresa Rettig,John Bawa,Justice Sylverken,David Sambian,Anima Sarfo,Alex Agyekum,Francis Martinson,Irving F. Hoffman,Tisungane Mvalo,Portia Kamthunzi,Rutendo Nkomo,Tapiwa Tembo,Gerald Tegha,Mercy Tsidya,Jane Kilembe,Chimwemwe Chawinga,W. Ripley Ballou,Joe Cohen,Yolanda Guerra,Erik Jongert,Didier Lapierre,Amanda J. Leach,Marc Lievens,Opokua Ofori-Anyinam,Aurélie Olivier,Johan Vekemans,Terrell Carter,David C. Kaslow,Didier Leboulleux,Christian Loucq,Afiya Radford,Barbara Savarese,David Schellenberg,Marla Sillman,Preeti Vansadia +168 more
TL;DR: The RTS,S/AS01 vaccine coadministered with EPI vaccines provided modest protection against both clinical and severe malaria in young infants.
Journal ArticleDOI
Mortality and morbidity from malaria in Gambian children after introduction of an impregnated bednet programme
Umberto D'Alessandro,B.O. Olaleye,William McGuire,P. Langerock,Sara Bennett,M. K. Aikins,Madeleine C. Thomson,M K Cham,B A Cham,Brian Greenwood +9 more
TL;DR: In a country such as The Gambia, where nets were widely used and which has a good primary health care system, it is possible to achieve insecticide-treatment of bednets at a national level with a significant reduction in child mortality; but at a cost which the country cannot afford.
Journal ArticleDOI
Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine
Daniel E. Neafsey,Michal Juraska,Trevor Bedford,David Benkeser,Clarissa Valim,Allison D. Griggs,Marc Lievens,Salim Abdulla,Samuel Adjei,Tsiri Agbenyega,Selidji T Agnandji,Pedro Aide,Scott Anderson,Daniel Ansong,John J. Aponte,Kwaku-Poku Asante,Philip Bejon,Ashley J. Birkett,Myriam Bruls,Kristen M Connolly,Umberto D'Alessandro,Carlota Dobaño,Samwel Gesase,Brian Greenwood,Jonna Grimsby,Halidou Tinto,Mary J. Hamel,Irving F. Hoffman,Portia Kamthunzi,Simon Kariuki,Peter G. Kremsner,Amanda J. Leach,Bertrand Lell,Niall Lennon,John Lusingu,Kevin Marsh,Francis Martinson,Jackson T Molel,Eli L. Moss,Patricia Njuguna,Christian F. Ockenhouse,Bernhards Ogutu,Walter Otieno,Lucas Otieno,Kephas Otieno,Seth Owusu-Agyei,Daniel J. Park,Karell G. Pellé,Dana Robbins,Carsten Russ,Elizabeth M. Ryan,Jahit Sacarlal,Brian Sogoloff,Hermann Sorgho,Marcel Tanner,Thor G. Theander,Innocent Valea,Sarah K Volkman,Qing Yu,Didier Lapierre,Bruce W. Birren,Peter B. Gilbert,Dyann F. Wirth +62 more
TL;DR: It is suggested that among children 5 to 17 months of age, the RTS,S vaccine has greater activity against malaria parasites with the matched circumsporozoite protein allele than against mismatched malaria.
Journal ArticleDOI
The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa
Maud Lemoine,Maud Lemoine,Yusuke Shimakawa,Yusuke Shimakawa,Shevanthi Nayagam,Mustapha Khalil,Penda Suso,Jo Lloyd,Robert D. Goldin,Harr-Freeya Njai,Gibril Ndow,Makie Taal,Graham S Cooke,Umberto D'Alessandro,Muriel Vray,Papa Saliou Mbaye,Ramou Njie,Vincent Mallet,Mark Thursz +18 more
TL;DR: The GPR is a more accurate routine laboratory marker than APRI and Fib-4 to stage liver fibrosis in patients with CHB in West Africa and represents a simple and inexpensive alternative to liver biopsy and Fibroscan in sub-Saharan Africa.