U
Upasana Roy
Researcher at Columbia University
Publications - 10
Citations - 303
Upasana Roy is an academic researcher from Columbia University. The author has contributed to research in topics: Homologous recombination & RAD51. The author has an hindex of 3, co-authored 10 publications receiving 39 citations. Previous affiliations of Upasana Roy include Stony Brook University.
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Journal ArticleDOI
Computed structures of core eukaryotic protein complexes.
Ian R. Humphreys,Jimin Pei,Minkyung Baek,Aditya Krishnakumar,Ivan Anishchenko,Sergey Ovchinnikov,Jing Zhang,Travis J. Ness,Sudeep Banjade,Saket R. Bagde,Viktoriya G. Stancheva,Xiao-Han Li,Kaixian Liu,Zhi Zheng,Zhi Zheng,Daniel J. Barrero,Upasana Roy,Jochen Kuper,Israel S. Fernández,Barnabas Szakal,Dana Branzei,Josep Rizo,Caroline Kisker,Eric C. Greene,Sue Biggins,Scott Keeney,Scott Keeney,Elizabeth A. Miller,J. Christopher Fromme,Tamara L. Hendrickson,Qian Cong,David Baker +31 more
TL;DR: The structures of many eukaryotic protein complexes are unknown, and there are likely many protein-protein interactions not yet identified as mentioned in this paper, but these structures play critical roles in biology.
Journal ArticleDOI
The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
Upasana Roy,Youngho Kwon,Lea Marie,Lorraine S. Symington,Patrick Sung,Michael Lisby,Eric C. Greene +6 more
TL;DR: In this article, the authors used single-molecule imaging to reveal that the Rad51 paralog complex Rad55-Rad57 promotes assembly of Rad51 recombinase filament through transient interactions, providing evidence that it acts like a classical molecular chaperone.
Posted ContentDOI
Rad51 paralog complex Rad55–Rad57 acts as a molecular chaperone during homologous recombination. Roy et al.
TL;DR: Single–molecule imaging is used to reveal that the Saccharomyces cerevisiae Rad51 paralog complex Rad55–Rad57 promotes the assembly of Rad51 recombinase filaments through transient interactions, providing evidence that it acts as a classical molecular chaperone.
Journal ArticleDOI
Bypass of DNA interstrand crosslinks by a Rev1-DNA polymerase ζ complex.
Rachel Bezalel-Buch,Young K. Cheun,Upasana Roy,Upasana Roy,Orlando D. Schärer,Peter M. J. Burgers +5 more
TL;DR: No stalling by Rev1–Pol ζ directly past the ICL was observed, suggesting that the proposed function of Pol ζ as an extender DNA polymerase is also required for ICL repair.
Posted ContentDOI
Structures of core eukaryotic protein complexes
Ian R. Humphreys,Jimin Pei,Minkyung Baek,Krishnakumar A,Ivan Anishchenko,Sergey Ovchinnikov,Jianhua Zhang,Travis J. Ness,Sudeep Banjade,Saket R. Bagde,Viktoriya G. Stancheva,Xiao-Han Li,Kaixian Liu,Zheng Z,Zheng Z,Barrero Dj,Upasana Roy,Fernández Is,Barnabas Szakal,Dana Branzei,Eric C. Greene,Biggins S,Scott Keeney,Scott Keeney,Elizabeth A. Miller,Fromme Jc,Hendrickson Tl,Qian Cong,David Baker,David Baker +29 more
TL;DR: In this article, a combination of RoseTTAFold and AlphaFold is used to screen through paired multiple sequence alignments for 8.3 million pairs of S. cerevisiae proteins and build models for strongly predicted protein assemblies.