Uta Ceglarek

TL;DR: Seven T2D‐related genes are identified that are associated with these three IGT‐specific metabolites by multiple interactions with four enzymes, and the expression levels of these enzymes correlate with changes in the metabolite concentrations linked to diabetes.

TL;DR: This study shows that reproducibility was good in both plasma and serum, and better in plasma, and as long as the same blood preparation procedure is used, either matrix should generate similar results in clinical and biological studies.

TL;DR: The objective is to investigate prevalences, early onset markers, genetic predispositions, and the role of lifestyle factors of major civilization diseases, with primary focus on metabolic and vascular diseases, heart function, cognitive impairment, brain function, depression, sleep disorders and vigilance dysregulation, retinal and optic nerve degeneration, and allergies.

TL;DR: Application of the standardized preanalytical blood sampling and storage procedure in combination with magnetic bead-based fractionation decreases variability of proteome patterns in human serum assessed by MALDI-TOF MS.

TL;DR: This reliable pretreatment protocol allows standardization of preanalytical modalities and facilitates reproducible peptidome profiling of human urine by means of magnetic bead separation followed by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS).