scispace - formally typeset
N

Norbert Dahmen

Researcher at University of Mainz

Publications -  167
Citations -  10077

Norbert Dahmen is an academic researcher from University of Mainz. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 47, co-authored 165 publications receiving 8884 citations. Previous affiliations of Norbert Dahmen include University of Oulu & University of New South Wales.

Papers
More filters
Journal ArticleDOI

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Bjarni J. Vilhjálmsson, +394 more
TL;DR: LDpred is introduced, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel, and outperforms the approach of pruning followed by thresholding, particularly at large sample sizes.
Journal ArticleDOI

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.

Thorgeir E. Thorgeirsson, +106 more
- 01 May 2010 - 
TL;DR: The authors conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium.
Journal ArticleDOI

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Jason Z. Liu, +107 more
- 01 May 2010 - 
TL;DR: The Oxford-GlaxoSmithKline study (Ox-GSK) as discussed by the authors performed a genome-wide meta-analysis of SNP association with smoking-related behavioral traits and found an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19) that includes CHRNA5, CHRNA3 and CHRNB4.
Journal ArticleDOI

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Raymond K. Walters, +171 more
- 26 Nov 2018 - 
TL;DR: The largest genome-wide association study to date of DSM-IV-diagnosed AD found loci associated with AD and characterized the relationship between AD and other psychiatric and behavioral outcomes, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.
Journal ArticleDOI

Genome-wide association studies identify four ER negative-specific breast cancer risk loci

Montserrat Garcia-Closas, +287 more
- 01 Apr 2013 - 
TL;DR: SNPs at four loci were associated with ER-negative but not ER-positive breast cancer (P > 0.05), providing further evidence for distinct etiological pathways associated with invasive ER- positive and ER- negative breast cancers.