V
Vassilios J. Bezzerides
Researcher at Boston Children's Hospital
Publications - 51
Citations - 1859
Vassilios J. Bezzerides is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Catecholaminergic polymorphic ventricular tachycardia & Medicine. The author has an hindex of 15, co-authored 44 publications receiving 1343 citations. Previous affiliations of Vassilios J. Bezzerides include Howard Hughes Medical Institute & Children's Medical Center of Dallas.
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Journal ArticleDOI
Rapid vesicular translocation and insertion of TRP channels
Vassilios J. Bezzerides,Vassilios J. Bezzerides,I. Scott Ramsey,Suhas A. Kotecha,Anna Greka,Anna Greka,David E. Clapham +6 more
TL;DR: It is reported that growth factor stimulation initiates the rapid translocation of the transient receptor potential ion channel, TRPC5, from vesicles held in reserve just under the plasma membrane, resulting in tight spatial–temporal control of these Ca2+-permeant nonselective channels.
Journal ArticleDOI
miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling
Xiaojun Liu,Junjie Xiao,Han Zhu,Xin Wei,Colin Platt,Federico Damilano,Chunyang Xiao,Vassilios J. Bezzerides,Vassilios J. Bezzerides,Pontus Boström,Lin Che,Chunxiang Zhang,Bruce M. Spiegelman,Anthony Rosenzweig,Anthony Rosenzweig +14 more
TL;DR: In this article, microRNA-222 (miR-222) was upregulated in two distinct models of exercise and found that it was sufficient to protect the heart against adverse remodeling.
Journal ArticleDOI
Activin type II receptor signaling in cardiac aging and heart failure.
Jason D. Roh,Ryan Hobson,Vinita Chaudhari,Pablo A. Quintero,Ashish Yeri,Mark D. Benson,Chunyang Xiao,Daniel A. Zlotoff,Vassilios J. Bezzerides,Nicholas E. Houstis,Colin Platt,Federico Damilano,Brian R. Lindman,Sammy Elmariah,Michael Biersmith,Se-Jin Lee,Christine E. Seidman,Christine E. Seidman,Christine E. Seidman,Jonathan G. Seidman,Robert E. Gerszten,Estelle Lach-Trifilieff,David J. Glass,Anthony Rosenzweig +23 more
TL;DR: It is suggested that increased activin/ActRII signaling links aging and HF pathobiology and that targeted inhibition of this catabolic pathway holds promise as a therapeutic strategy for multiple forms of HF.
Journal ArticleDOI
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth
Zhiqiang Lin,Haidong Guo,Haidong Guo,Yuan Cao,Yuan Cao,Sylvia Zohrabian,Pingzhu Zhou,Qing Ma,Nathan J. VanDusen,Yuxuan Guo,Jin Zhang,Sean M. Stevens,Feng Liang,Qimin Quan,Pim R.R. van Gorp,Amy Li,Cristobal G. dos Remedios,Aibin He,Vassilios J. Bezzerides,William T. Pu,William T. Pu +20 more
TL;DR: An acetylation-mediated, VGLL4-dependent switch that regulates TEAD stability and YAP-TEAD activity is defined that may improve targeted modulation of TEAD-YAP activity in applications from cardiac regeneration to cancer.
Journal ArticleDOI
Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation
Donghui Zhang,Yifei Li,Danielle A. Heims-Waldron,Vassilios J. Bezzerides,Silvia Guatimosim,Yuxuan Guo,Fei Gu,Pingzhu Zhou,Zhiqiang Lin,Qing Ma,Jianming Liu,Da-Zhi Wang,William T. Pu +12 more
TL;DR: A transient window during the first postnatal week when inhibition of ROS or the DNA damage response pathway ameliorated the detrimental effect of Tfam inactivation is identified, and normal mitochondrial function was not required for cardiomyocyte maturation.