V
Venu Pullabhatla
Researcher at King's College London
Publications - 14
Citations - 1164
Venu Pullabhatla is an academic researcher from King's College London. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 9, co-authored 14 publications receiving 960 citations. Previous affiliations of Venu Pullabhatla include National Institute for Health Research & Guy's and St Thomas' NHS Foundation Trust.
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Journal ArticleDOI
Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis
Alexandros Onoufriadis,Michael A. Simpson,Andrew Pink,Paola Di Meglio,Catherine H. Smith,Venu Pullabhatla,Jo Knight,Sarah L. Spain,Frank O. Nestle,A. David Burden,Francesca Capon,Richard C. Trembath,Jonathan Barker +12 more
TL;DR: Findings suggest loss of function of IL36RN as the genetic basis of GPP and implicate innate immune dysregulation in this severe episodic inflammatory disease, thereby highlighting IL-1 signaling as a potential target for therapeutic intervention.
Journal ArticleDOI
Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema
Maria Quaranta,Bettina Knapp,Natalie Garzorz,M. Mattii,Venu Pullabhatla,Davide Pennino,Christian Andres,Claudia Traidl-Hoffmann,Andrea Cavani,Fabian J. Theis,Johannes Ring,Carsten B. Schmidt-Weber,Stefanie Eyerich,Kilian Eyerich +13 more
TL;DR: It is found that psoriasis-specific genes involved not only immune mediators but also regulators of metabolism and eczema-related genes included those related to the epidermal barrier and inflammasome activation.
Journal ArticleDOI
Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes.
Niovi Setta-Kaffetzi,Alexander A. Navarini,Varsha M. Patel,Venu Pullabhatla,Andrew Pink,Siew Eng Choon,M Allen,A. David Burden,Christopher E.M. Griffiths,Marieke M B Seyger,Brian Kirby,Richard C. Trembath,Richard C. Trembath,Michael A. Simpson,Catherine H. Smith,Francesca Capon,Jonathan Barker +16 more
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Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.
Chrysothemis C. Brown,Daria Esterházy,Aurelien Sarde,Mariya London,Venu Pullabhatla,Ines Osma-Garcia,Raya al-Bader,Carla Ortiz,Raul Elgueta,Matthew Arno,Emanuele de Rinaldis,Emanuele de Rinaldis,Daniel Mucida,Graham M. Lord,Graham M. Lord,Randolph J. Noelle,Randolph J. Noelle +16 more
TL;DR: This study finds that RA, through its receptor RARα, sustains stable expression of Th1 lineage specifying genes, as well as repressing genes that instruct Th17-cell fate, and defines an additional pathway for the development of Th17 cells.
Journal ArticleDOI
Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome.
Wesley J. Woollard,Venu Pullabhatla,Anna Lorenc,Varsha M. Patel,Rosie M. Butler,Anthony Bayega,Nelema Begum,Farrah S. Bakr,Kiran Dedhia,Joshua Fisher,Silvia Aguilar-Duran,Charlotte E. Flanagan,Aria A. Ghasemi,Ricarda M. Hoffmann,Nubia Castillo-Mosquera,Elisabeth A. Nuttall,Arisa Paul,Ceri A. Roberts,Emmanouil G Solomonidis,Rebecca Tarrant,Antoinette Yoxall,Carl Z. Beyers,Silvia Ferreira,Isabella Tosi,Michael A. Simpson,Emanuele de Rinaldis,Tracey J. Mitchell,Sean Whittaker +27 more
TL;DR: This study provides the basis for a detailed functional analysis of malignant transformation of mature T cells and improved patient stratification and treatment in SS.