V
Veronique A. J. Smits
Researcher at Hospital Universitario de Canarias
Publications - 41
Citations - 2876
Veronique A. J. Smits is an academic researcher from Hospital Universitario de Canarias. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 22, co-authored 39 publications receiving 2597 citations. Previous affiliations of Veronique A. J. Smits include Erasmus University Rotterdam & Utrecht University.
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Journal ArticleDOI
Polo-like kinase-1 is a target of the DNA damage checkpoint.
Veronique A. J. Smits,Rob Klompmaker,Lionel Arnaud,Lionel Arnaud,Gert Rijksen,Erich A. Nigg,Erich A. Nigg,René H. Medema +7 more
TL;DR: It is proposed that Plk1 is an important target of the DNA damage checkpoint, enabling cell-cycle arrests at multiple points in G2 and mitosis, and blocking mitotic exit.
Journal ArticleDOI
Checking out the G(2)/M transition.
TL;DR: This review focuses on the factors controlling the transition from G(2) phase to mitosis and the pathways contributing to the DNA damage checkpoints in these phases of the cell cycle.
Journal ArticleDOI
Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery
Ivan Mamely,Marcel A. T. M. van Vugt,Veronique A. J. Smits,Jennifer I. Semple,Bennie B. L. G. Lemmens,Anastassis Perrakis,René H. Medema,Raimundo Freire +7 more
TL;DR: Claspin levels are tightly regulated, both during unperturbed cell cycles and after DNA damage, and the degradation of Claspin at the onset of mitosis is an essential step for the recovery of a cell from a DNA-damage-induced cell-cycle arrest.
Journal ArticleDOI
p21 inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA damage checkpoint
Veronique A. J. Smits,Rob Klompmaker,Tea Vallenius,Gert Rijksen,Tomi P. Mäkelä,René H. Medema +5 more
TL;DR: The mechanism by which p21 can contribute to this arrest in G2 is addressed, and data show that a cell is equipped with at least two independent pathways to ensure efficient inhibition of Cdc2 activity in response to DNA damage.
Journal ArticleDOI
Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response
TL;DR: It is proposed that in response to DNA damage, PIKK-dependent checkpoint signaling leads to phosphorylation of chromatin-bound Chk1, resulting in its rapid release from chromatin and facilitating the transmission of DNA-damage signals to downstream targets, thereby promoting efficient cell-cycle arrest.