V
Victor Ruotti
Researcher at Morgridge Institute for Research
Publications - 18
Citations - 20761
Victor Ruotti is an academic researcher from Morgridge Institute for Research. The author has contributed to research in topics: Reprogramming & Induced pluripotent stem cell. The author has an hindex of 14, co-authored 15 publications receiving 19308 citations. Previous affiliations of Victor Ruotti include Medical College of Wisconsin & University of Wisconsin-Madison.
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Journal ArticleDOI
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,Maxim A. Vodyanik,Kim Smuga-Otto,Jessica Antosiewicz-Bourget,Jennifer L. Frane,Shulan Tian,Jeff Nie,Gudrun A. Jonsdottir,Victor Ruotti,Ron Stewart,Igor I. Slukvin,James A. Thomson +11 more
TL;DR: This article showed that OCT4, SOX2, NANOG, and LIN28 factors are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells.
Journal ArticleDOI
Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.
Supporting Online Material for Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,Maxim A. Vodyanik,Kim Smuga-Otto,Jessica Antosiewicz-Bourget,Jennifer L. Frane,Shulan Tian,Jeff Nie,Gudrun A. Jonsdottir,Victor Ruotti,Ron M. Stewart,Igor I. Slukvin,James A. Thomson +11 more
TL;DR: Yu et al. as discussed by the authors proposed online material for induced pluripotent stem cell lines derived from human Somatic Cells, which can be used for transplanting human stem cells to humans.
Journal ArticleDOI
EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments.
Ning Leng,John A. Dawson,James A. Thomson,Victor Ruotti,Anna I. Rissman,Bart M. G. Smits,Jill D. Haag,Michael N. Gould,Ron Stewart,Christina Kendziorski +9 more
TL;DR: EBSeq is developed, using the merits of empirical Bayesian methods, for identifying DE isoforms in an RNA-seq experiment comparing two or more biological conditions and proves to be a robust approach for identifying De genes.
Journal ArticleDOI
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
R. David Hawkins,Gary C. Hon,Leonard Lee,Que-Minh Ngo,Ryan Lister,Mattia Pelizzola,Lee Edsall,Samantha Kuan,Ying Luu,Sarit Klugman,Jessica Antosiewicz-Bourget,Zhen Ye,Celso A. Espinoza,Saurabh Agarwahl,Li Shen,Victor Ruotti,Victor Ruotti,Wei Wang,Ron Stewart,Ron Stewart,James A. Thomson,Joseph R. Ecker,Bing Ren,Bing Ren +23 more
TL;DR: By comparing the chromatin-modification profiles and DNA methylomes in hESCs and primary fibroblasts, it is found that nearly one-third of the genome differs in chromatin structure.