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Nick Andrews
Researcher at Boston Children's Hospital
Publications - 67
Citations - 3364
Nick Andrews is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Anxiogenic & Diazepam. The author has an hindex of 29, co-authored 60 publications receiving 2711 citations. Previous affiliations of Nick Andrews include Organon International & Guy's Hospital.
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Comparative Study of Pre- and Postsynaptic 5-HT1AReceptor Modulation of Anxiety in Two Ethological Animal Tests
TL;DR: Evidence is provided that stimulation of the presynaptic 5-HT1A receptors in the median raphénucleus results in an anxiolytic action, whereas stimulation of those of the post-synaptic 4- HT1Areceptors in its projection area of the dorsal hippocampus results in a anxiogenic effect.
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5-HT1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze
TL;DR: Either the two tests have different sensitivities to midazolam and 8-OH-DPAT or more intriguingly, the tests are evoking fundamentally different states of anxiety, with that evoked by the plus-maze being mediated via brain areas or receptors different from those studied here.
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Does age matter? The impact of rodent age on study outcomes
Samuel J. Jackson,Nick Andrews,Doug Ball,Ilaria Bellantuono,James Gray,Lamia Hachoumi,Alan Holmes,Judy Latcham,Anja Petrie,Paul Potter,Andrew S.C. Rice,A.A. Ritchie,Michelle Stewart,Carol Strepka,Mark Yeoman,Kathryn Chapman +15 more
TL;DR: It is highlighted that choice of age is inconsistent across the research community and often not based on the development or cellular ageing of the system being studied, which could potentially result in decreased scientific validity and increased experimental variability.
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Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety
Nick Andrews,Sandra E. File +1 more
TL;DR: In rats naive to handling, but not in handling-habituated animals, baclofen and (R,S) zacopride had significant anxiolytic effects, shown by an increased percentage of time spent on the open arms of the elevated plus-maze.
Journal ArticleDOI
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Shane J. F. Cronin,Shane J. F. Cronin,Shane J. F. Cronin,Corey R. Seehus,Corey R. Seehus,Adelheid Weidinger,Sébastien Talbot,Sébastien Talbot,Sébastien Talbot,Sonja Reissig,Markus Seifert,Yann Pierson,Eileen McNeill,Eileen McNeill,Maria Serena Longhi,Bruna Lenfers Turnes,Taras Kreslavsky,Taras Kreslavsky,Melanie Kogler,David Hoffmann,Melita Ticevic,Débora da Luz Scheffer,Luigi Tortola,Domagoj Cikes,Alexander Jais,Manu Rangachari,Shuan Rao,Magdalena Paolino,Maria Novatchkova,Martin Aichinger,Lee Barrett,Lee Barrett,Alban Latremoliere,Gerald Wirnsberger,Guenther Lametschwandtner,Meinrad Busslinger,Stephen Zicha,Alexandra Latini,Alexandra Latini,Alexandra Latini,Simon C. Robson,Simon C. Robson,Ari Waisman,Nick Andrews,Nick Andrews,Michael Costigan,Keith M. Channon,Keith M. Channon,Guenter Weiss,Andrey V. Kozlov,Mark Joseph Tebbe,Kai Johnsson,Kai Johnsson,Clifford J. Woolf,Clifford J. Woolf,Josef M. Penninger +55 more
TL;DR: The data uncover GCH1, SPR and their downstream metabolite BH4 as critical regulators of T cell biology that can be readily manipulated to either block autoimmunity or enhance anticancer immunity.