Jason A. Skinner

TL;DR: A hitherto underappreciated role of type I IFN-αβ signalling in the pathogenesis of TB is demonstrated, which has implications for vaccine and therapeutic development and a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the TB epidemic are provided.

TL;DR: The innate response was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination, suggesting that comparing global immune responses elicited by different vaccines will be critical to the understanding of the immune mechanisms underpinning successful vaccination.

TL;DR: It is concluded that over-expression of a subset of IFN-stimulated genes in chronic HTLV-1 infection does not constitute an efficient host response but instead contributes to the development of HAM/TSP.

TL;DR: Findings indicate that persistent colonization by B. bronchiseptica may rely on the ability of the bacteria to differentially modulate both macrophage and dendritic cell function leading to an altered adaptive immune response and subsequent bacterial colonization.

TL;DR: The time-course gene set analysis (TcGSA) introduced here is an extension of gene setAnalysis to longitudinal data that relies on random effects modeling with maximum likelihood estimates and exhibits good statistical properties, and an increased power compared to other approaches for analyzing time- Course expression patterns of gene sets.