K
Kenneth Bachmann
Researcher at University of Toledo
Publications - 99
Citations - 2821
Kenneth Bachmann is an academic researcher from University of Toledo. The author has contributed to research in topics: Theophylline & Ethosuximide. The author has an hindex of 26, co-authored 99 publications receiving 2689 citations. Previous affiliations of Kenneth Bachmann include University of Toledo Medical Center.
Papers
More filters
Journal ArticleDOI
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
Edward J. Calabrese,Kenneth Bachmann,A. John Bailer,P. Michael Bolger,Jonathan Borak,Lu Cai,Nina Cedergreen,M. George Cherian,Chuang Chin Chiueh,Thomas W. Clarkson,Ralph R. Cook,David M. Diamond,David J. Doolittle,Michael A. Dorato,Stephen O. Duke,Ludwig E. Feinendegen,Donald E. Gardner,Ronald W. Hart,Kenneth L. Hastings,A. Wallace Hayes,George R. Hoffmann,John A. Ives,Zbigniew Jaworowski,Thomas E. Johnson,Wayne B. Jonas,Norbert E. Kaminski,John G. Keller,James E. Klaunig,Thomas B. Knudsen,Walter J. Kozumbo,Teresa Lettieri,Shu Zheng Liu,Andre Maisseu,Kenneth I. Maynard,Edward J. Masoro,Roger O. McClellan,Harihara M. Mehendale,Carmel Mothersill,David B. Newlin,Herbert N. Nigg,Frederick W. Oehme,Robert F. Phalen,Martin A. Philbert,Suresh I. S. Rattan,Jim E. Riviere,Joseph Rodricks,Robert M. Sapolsky,Bobby R. Scott,Colin Seymour,David A. Sinclair,Joan Smith-Sonneborn,Elizabeth T. Snow,Linda P. Spear,Donald E. Stevenson,Yolene Thomas,Maurice Tubiana,Gary M. Williams,Mark P. Mattson +57 more
TL;DR: This article offers a set of recommendations that scientists believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
Journal ArticleDOI
Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites
Sean Ekins,Cheng Chang,Sridhar Mani,Matthew D. Krasowski,Erica J. Reschly,Manisha Iyer,Vladyslav Kholodovych,Ni Ai,William J. Welsh,Michael Sinz,Peter W. Swaan,Rachana Patel,Kenneth Bachmann +12 more
TL;DR: Combining computational and experimental data for different classes of molecules provided strong evidence for agonists and antagonists binding distinct regions on PXR, and bear significant implications for future discovery of molecules that are more selective and potent antagonists.
Book
Pharmacology : principles and practice
TL;DR: This unique and much needed textbook meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine.
Journal ArticleDOI
Scaling basic toxicokinetic parameters from rat to man.
TL;DR: Based on a data set of about 100 different xenobiotics, it is found that values for half-life and volume of distribution of a xenobiotic in humans can be predicted from the estimates of those parameters in rats.
Journal ArticleDOI
Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans
Jules I. Schwartz,Chi‐Chung Chan,Saurabh Mukhopadhyay,Kathleen J. McBride,Terry M. Jones,Sherilyn Adcock,Carl Moritz,Jerris Hedges,Kenneth Grasing,David Dobratz,Robert A. Cohen,Michael H. Davidson,Kenneth Bachmann,Barry J. Gertz +13 more
TL;DR: The data support the hypothesis that it is the COX‐2 isoform that is primarily involved in the genesis of fever in humans and results in antipyretic activity in monkeys and humans comparable to dual COX'1/COX'2 inhibitors such as diclofenac or ibuprofen.