W
Waldionê de Castro
Researcher at National Institutes of Health
Publications - 10
Citations - 236
Waldionê de Castro is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Leishmania infantum & Leishmania. The author has an hindex of 5, co-authored 10 publications receiving 165 citations. Previous affiliations of Waldionê de Castro include Universidade Federal de Minas Gerais.
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Journal ArticleDOI
Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β
Ranadhir Dey,Amritanshu B. Joshi,Fabiano Oliveira,Lais Pereira,Lais Pereira,Anderson B. Guimarães-Costa,Tiago D. Serafim,Waldionê de Castro,Iliano V. Coutinho-Abreu,Parna Bhattacharya,Shannon Townsend,Hamide Aslan,Alec Perkins,Subir Karmakar,Nevien Ismail,Morgan Karetnick,Claudio Meneses,Robert Duncan,Hira L. Nakhasi,Jesus G. Valenzuela,Shaden Kamhawi +20 more
TL;DR: It is demonstrated that gut microbes from the sand fly are egested into host skin alongside Leishmania parasites, indicating that both gut microbiota and IL-1β are important for the establishment of Leishmaniasis infections.
Journal ArticleDOI
Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infection
Eric Henrique Roma,Eric Henrique Roma,Juan Pereira de Macêdo,Grazielle Ribeiro Goes,Juliana Lauar Gonçalves,Juliana Lauar Gonçalves,Waldionê de Castro,Waldionê de Castro,Daniel Cisalpino,Leda Quercia Vieira +9 more
TL;DR: ROS do not seem to be important to parasite killing in vivo, but they regulate the inflammatory response probably by controlling neutrophils numbers in lesions at early stages of infection.
Journal ArticleDOI
A sand fly salivary protein acts as a neutrophil chemoattractant.
Anderson B. Guimarães-Costa,Anderson B. Guimarães-Costa,John P. Shannon,Ingrid Waclawiak,Jullyanna Oliveira,Claudio Meneses,Waldionê de Castro,Xi Wen,Joseph Brzostowski,Tiago D. Serafim,John F. Andersen,Heather D. Hickman,Shaden Kamhawi,Jesus G. Valenzuela,Fabiano Oliveira +14 more
TL;DR: In this paper, a sand fly salivary protein that induces neutrophil chemotaxis and explore its impact in a model of parasitic infection was characterized. But the structure of this chemoattractant protein does not resemble that of known chemokines.
Journal ArticleDOI
Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites.
Nívea F. Luz,Thiago DeSouza-Vieira,Waldionê de Castro,Áislan de Carvalho Vivarini,Lais Pereira,Riam Rocha França,Riam Rocha França,Paulo S. Silveira-Mattos,Paulo S. Silveira-Mattos,Diego L. Costa,Clarissa Teixeira,Claudio Meneses,Viviane Boaventura,Viviane Boaventura,Camila I. de Oliveira,Camila I. de Oliveira,Ulisses Gazos Lopes,Naomi E. Aronson,Bruno B. Andrade,Bruno B. Andrade,Cláudia Brodskyn,Cláudia Brodskyn,Jesus G. Valenzuela,Shaden Kamhawi,Valéria M. Borges,Valéria M. Borges +25 more
TL;DR: It is demonstrated that vector saliva induces early HO-1 production at the bite sites, representing a major event associated with establishment of naturally-transmitted Leishmania infections.
Journal ArticleDOI
Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis.
Oluwatoyin A. Asojo,Alan Kelleher,Zhuyun Liu,Jeroen Pollet,Elissa M. Hudspeth,Wanderson C. Rezende,Mallory Jo Groen,Christopher A. Seid,Maha Abdeladhim,Shannon Townsend,Waldionê de Castro,Antonio Ferreira Mendes-Sousa,Daniella Castanheira Bartholomeu,Ricardo Toshio Fujiwara,Maria Elena Bottazzi,Maria Elena Bottazzi,Peter J. Hotez,Peter J. Hotez,Bin Zhan,Fabiano Oliveira,Shaden Kamhawi,Jesus G. Valenzuela +21 more
TL;DR: Results indicate that SALO as expressed and purified from P. pastoris is suitable for further scale-up, manufacturing, and testing and does not have the anti-complement activity observed in the native salivary protein which are all important attributes to move this vaccine candidate forward to the clinical path.