J
Jordan L. Woehl
Researcher at Scripps Research Institute
Publications - 22
Citations - 1648
Jordan L. Woehl is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Antibody & Complement system. The author has an hindex of 8, co-authored 17 publications receiving 1075 citations. Previous affiliations of Jordan L. Woehl include Kansas State University & International AIDS Vaccine Initiative.
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Journal ArticleDOI
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.
Thomas F. Rogers,Thomas F. Rogers,Fangzhu Zhao,Deli Huang,Nathan Beutler,Alison Burns,Wan-ting He,Oliver Limbo,Oliver Limbo,Chloe Smith,Ge Song,Jordan L. Woehl,Jordan L. Woehl,Linlin Yang,Robert K. Abbott,Robert K. Abbott,Sean Callaghan,Elijah Garcia,Jonathan Hurtado,Mara Parren,Linghang Peng,Sydney I. Ramirez,James Ricketts,Michael J. Ricciardi,Stephen A. Rawlings,Nicholas C. Wu,Meng Yuan,Davey M. Smith,David Nemazee,John R. Teijaro,James E. Voss,Ian A. Wilson,Raiees Andrabi,Bryan Briney,Elise Landais,Devin Sok,Joseph G. Jardine,Joseph G. Jardine,Dennis R. Burton +38 more
TL;DR: A role for potent neutralizing antibodies (nAbs) in prophylaxis, and potentially therapy, of COVID-19 is suggested, as indicated by maintained weight and low lung viral titers in treated animals, and the passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters.
Journal ArticleDOI
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Qinheng Zheng,Jordan L. Woehl,Seiya Kitamura,Diogo Santos-Martins,Christopher J. Smedley,Gencheng Li,Stefano Forli,John E. Moses,Dennis W. Wolan,K. Barry Sharpless +9 more
TL;DR: Evaluation of the ever-growing collection of SuFExable compounds toward various biological assays unexpectedly revealed a selective and covalent hNE inhibitor: benzene-1,2-disulfonyl fluoride.
Journal ArticleDOI
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
Seiya Kitamura,Qinheng Zheng,Jordan L. Woehl,Angelo Solania,Emily I. Chen,Nicholas Dillon,Mitchell V. Hull,Miyako Kotaniguchi,John R. Cappiello,Shinichi Kitamura,Victor Nizet,K. Barry Sharpless,Dennis W. Wolan +12 more
TL;DR: A high-throughput hit-to-lead process based on the biocompatible SuFEx click chemistry that succeeds on picomole scale for direct screening and can accelerate the development of robust biological probes and drug candidates is demonstrated.
Posted ContentDOI
Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model.
Thomas F. Rogers,Thomas F. Rogers,Fangzhu Zhao,Deli Huang,Nathan Beutler,Alison Burns,Wan-ting He,Oliver Limbo,Oliver Limbo,Chloe Smith,Ge Song,Jordan L. Woehl,Jordan L. Woehl,Linlin Yang,Robert K. Abbott,Sean Callaghan,Elijah Garcia,Jonathan Hurtado,Mara Parren,Linghang Peng,James Ricketts,Michael J. Ricciardi,Stephen A. Rawlings,Davey M. Smith,David Nemazee,John R. Teijaro,James E. Voss,Raiees Andrabi,Bryan Briney,Elise Landais,Elise Landais,Devin Sok,Joseph G. Jardine,Joseph G. Jardine,Dennis R. Burton +34 more
TL;DR: The study suggests a role for nAbs in prophylaxis, and potentially therapy, of COVID-19 and shows that passive transfer of a nAb provides protection against high-dose SARS-CoV-2 challenge in Syrian hamsters.
Journal ArticleDOI
The Extracellular Adherence Protein from Staphylococcus aureus Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase
Jordan L. Woehl,Daphne A.C. Stapels,Brandon L. Garcia,Kasra X. Ramyar,Andrew Keightley,Maartje Ruyken,Maria Syriga,Georgia Sfyroera,Alexander B. Weber,Michal Zolkiewski,Daniel Ricklin,John D. Lambris,Suzan H.M. Rooijakkers,Brian V. Geisbrecht,Brian V. Geisbrecht +14 more
TL;DR: The results demonstrate that S. aureus inhibits two initiation routes of complement by expression of the Eap protein, and thereby define a novel mechanism of immune evasion.