G
Ge Song
Researcher at Scripps Research Institute
Publications - 35
Citations - 2127
Ge Song is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Antibody & Biology. The author has an hindex of 8, co-authored 18 publications receiving 1077 citations. Previous affiliations of Ge Song include International AIDS Vaccine Initiative.
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Journal ArticleDOI
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.
Thomas F. Rogers,Thomas F. Rogers,Fangzhu Zhao,Deli Huang,Nathan Beutler,Alison Burns,Wan-ting He,Oliver Limbo,Oliver Limbo,Chloe Smith,Ge Song,Jordan L. Woehl,Jordan L. Woehl,Linlin Yang,Robert K. Abbott,Robert K. Abbott,Sean Callaghan,Elijah Garcia,Jonathan Hurtado,Mara Parren,Linghang Peng,Sydney I. Ramirez,James Ricketts,Michael J. Ricciardi,Stephen A. Rawlings,Nicholas C. Wu,Meng Yuan,Davey M. Smith,David Nemazee,John R. Teijaro,James E. Voss,Ian A. Wilson,Raiees Andrabi,Bryan Briney,Elise Landais,Devin Sok,Joseph G. Jardine,Joseph G. Jardine,Dennis R. Burton +38 more
TL;DR: A role for potent neutralizing antibodies (nAbs) in prophylaxis, and potentially therapy, of COVID-19 is suggested, as indicated by maintained weight and low lung viral titers in treated animals, and the passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters.
Journal ArticleDOI
Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection.
Ge Song,Wan ting He,Sean Callaghan,Fabio Anzanello,Deli Huang,James Ricketts,Jonathan L. Torres,Nathan Beutler,Linghang Peng,Sirena Vargas,Jon Cassell,Mara Parren,Linlin Yang,Caroline Ignacio,Davey M. Smith,James E. Voss,David Nemazee,Andrew B. Ward,Thomas F. Rogers,Thomas F. Rogers,Dennis R. Burton,Raiees Andrabi +21 more
TL;DR: In this paper, the authors compare serum antibody and memory B cell responses to coronavirus spike proteins from pre-pandemic and SARS-CoV-2 convalescent donors using binding and functional assays.
Journal ArticleDOI
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection
Panpan Zhou,Meng Yuan,Ge Song,Nathan Beutler,Namir Shaabani,Deli Huang,Wan-ting He,Xu-Dong Zhu,Sean Callaghan,Peter Yong,Fabio Anzanello,Linghang Peng,James Ricketts,Mara Parren,Elijah Garcia,Stephen A. Rawlings,Davey M. Smith,David Nemazee,John R. Teijaro,Thomas F. Rogers,Ian A. Wilson,Dennis R. Burton,Raiees Andrabi +22 more
TL;DR: The authors identified a human monoclonal antibody isolated from a convalescent donor, CC40.8, that bound to the SARS-CoV-2 S2 stem peptide, a region that is conserved across beta-coronaviruses.
Posted ContentDOI
Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection
Ge Song,Wan ting He,Sean Callaghan,Fabio Anzanello,Deli Huang,James Ricketts,Jonathan L. Torres,Nathan Beutler,Linghang Peng,Sirena Vargas,Jon Cassell,Mara Parren,Linlin Yang,Caroline Ignacio,Davey M. Smith,James E. Voss,David Nemazee,Andrew B. Ward,Thomas F. Rogers,Thomas F. Rogers,Dennis R. Burton,Raiees Andrabi +21 more
TL;DR: Pre-existing immunity to endemic coronaviruses should be considered in evaluating antibody responses to SARS-CoV-2, according to the nature and extent of cross-reactivity in humans to coronavirus spike proteins.
Posted ContentDOI
A protective broadly cross-reactive human antibody defines a conserved site of vulnerability on beta-coronavirus spikes
Panpan Zhou,Meng Yuan,Ge Song,Nathan Beutler,Namir Shaabani,Deli Huang,Wan-ting He,Xueyong Zhu,Sean Callaghan,Peter Yong,Fabio Anzanello,Linghang Peng,James Ricketts,Mara Parren,Elijah Garcia,Stephen A. Rawlings,Davey M. Smith,David Nemazee,John R. Teijaro,Thomas F. Rogers,Thomas F. Rogers,Ian A. Wilson,Dennis R. Burton,Raiees Andrabi +23 more
TL;DR: In this article, CC408 targets the conserved S2 stem-helix region of the coronavirus spike fusion machinery and exhibits broad reactivity with human β-CoVs.