S
Snaevar Sigurdsson
Researcher at RMIT University
Publications - 49
Citations - 5159
Snaevar Sigurdsson is an academic researcher from RMIT University. The author has contributed to research in topics: Single-nucleotide polymorphism & IRF5. The author has an hindex of 29, co-authored 45 publications receiving 4760 citations. Previous affiliations of Snaevar Sigurdsson include deCODE genetics & Uppsala University.
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Journal ArticleDOI
Genome sequence, comparative analysis, and population genetics of the domestic horse.
Claire M. Wade,Elena Giulotto,Snaevar Sigurdsson,Monica Zoli,Sante Gnerre,Freyja Imsland,Teri L. Lear,David L. Adelson,Ernest Bailey,Rebecca R. Bellone,Helmut Blöcker,Ottmar Distl,Robert C. Edgar,Manuel Garber,Tosso Leeb,Evan Mauceli,James N. MacLeod,Maria Cecilia T. Penedo,Joy M. Raison,Ted Sharpe,J. Vogel,Leif Andersson,Douglas F. Antczak,Tara Biagi,Matthew M. Binns,Bhanu P. Chowdhary,S.J. Coleman,G. Della Valle,Sarah Fryc,Gérard Guérin,T. Hasegawa,Emmeline W. Hill,Jerzy Jurka,Anna Kiialainen,Gabriella Lindgren,Jinze Liu,Elisa Magnani,James R. Mickelson,James D. Murray,Solomon G. Nergadze,Robert C. Onofrio,S. Pedroni,M. F. Piras,Terje Raudsepp,Mariano Rocchi,K. H. Røed,Oliver A. Ryder,S. Searle,Loren C. Skow,June E Swinburne,Ann-Christine Syvänen,Teruaki Tozaki,Stephanie J. Valberg,Mark Vaudin,Jared White,Michael C. Zody,Eric S. Lander,Kerstin Lindblad-Toh +57 more
TL;DR: The analysis reveals an evolutionarily new centromere on equine chromosome 11 that displays properties of an immature but fully functioning Centromere and is devoid of centromeric satellite sequence, suggesting thatCentromeric function may arise before satellite repeat accumulation.
Journal ArticleDOI
Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
Snaevar Sigurdsson,Gunnel Nordmark,Harald H H Göring,Katarina Lindroos,Ann-Christin Wiman,Gunnar Sturfelt,Andreas Jönsen,Solbritt Rantapää-Dahlqvist,Bozena Möller,Juha Kere,Sari Koskenmies,Elisabeth Widen,Maija-Leena Eloranta,Heikki Julkunen,Helga Kristjansdottir,Kristjan Steinsson,Gunnar V. Alm,Lars Rönnblom,Ann-Christine Syvänen +18 more
TL;DR: The results support a disease mechanism in SLE that involves key components of the type I IFN system, and identify SNPs that displayed strong signals in joint analysis of linkage and association with SLE.
Journal ArticleDOI
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
Robert R. Graham,Chieko Kyogoku,Snaevar Sigurdsson,Irina A. Vlasova,Leela Davies,Leela Davies,Emily C. Baechler,Robert M. Plenge,Robert M. Plenge,Thearith Koeuth,Ward A. Ortmann,Ward A. Ortmann,Geoffrey Hom,Geoffrey Hom,Jason W. Bauer,Clarence Gillett,Noël P. Burtt,Noël P. Burtt,Deborah S. Cunninghame Graham,Robert C. Onofrio,Robert C. Onofrio,Michelle Petri,Iva Gunnarsson,Elisabet Svenungsson,Lars Rönnblom,Gunnel Nordmark,Peter K. Gregersen,Kathy L. Moser,Patrick M. Gaffney,Lindsey A. Criswell,Timothy J. Vyse,Ann-Christine Syvänen,Paul R. Bohjanen,Mark J. Daly,Mark J. Daly,Timothy W. Behrens,Timothy W. Behrens,David Altshuler,David Altshuler +38 more
TL;DR: Evidence is found for three functional alleles of IRF5: the previously described exon 1B splice site variant, a 30-bp in-frame insertion/deletion variant of exon 6 that alters a proline-, glutamic acid-, serine- and threonine-rich domain region, and a variant in a conserved polyA+ signal sequence that alters the length of the 3′ UTR and stability of IRf5 mRNAs.
Journal ArticleDOI
Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping
Amaury Vaysse,Abhirami Ratnakumar,Thomas Derrien,Erik Axelsson,Gerli Pielberg,Snaevar Sigurdsson,Tove Fall,Eija H. Seppälä,Mark Hansen,Cindy Lawley,Elinor K. Karlsson,Danika L. Bannasch,Carles Vilà,Hannes Lohi,Francis Galibert,Merete Fredholm,Jens Häggström,Åke Hedhammar,Catherine André,Kerstin Lindblad-Toh,Christophe Hitte,Matthew T. Webster +21 more
TL;DR: This study provides a catalogue of genomic regions showing extreme reduction in genetic variation or population differentiation in dogs, including many linked to phenotypic variation.