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Weibo Li
Researcher at Harvard University
Publications - 7
Citations - 3923
Weibo Li is an academic researcher from Harvard University. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 6, co-authored 6 publications receiving 3079 citations. Previous affiliations of Weibo Li include Broad Institute & Massachusetts Institute of Technology.
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Journal ArticleDOI
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.
Alexandra-Chloé Villani,Alexandra-Chloé Villani,Rahul Satija,Rahul Satija,Gary Reynolds,Siranush Sarkizova,Karthik Shekhar,James Fletcher,Morgane Griesbeck,Andrew Butler,Shiwei Zheng,Suzan Lazo,Laura Jardine,David Dixon,Emily Stephenson,Emil Nilsson,Ida Grundberg,David McDonald,Andrew Filby,Weibo Li,Weibo Li,Philip L. De Jager,Philip L. De Jager,Orit Rozenblatt-Rosen,Andrew A. Lane,Andrew A. Lane,Muzlifah Haniffa,Muzlifah Haniffa,Aviv Regev,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +32 more
TL;DR: This refined analysis has identified, among others, a previously unknown dendritic cell population that potently activates T cells and reclassify pDCs as the originally described “natural interferon-producing cells (IPCs)” with weaker T cell proliferation induction ability.
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Alexandra-Chloé Villani,Alexandra-Chloé Villani,Rahul Satija,Rahul Satija,Gary Reynolds,Siranush Sarkizova,Karthik Shekhar,James Fletcher,Morgane Griesbeck,Andrew Butler,Shiwei Zheng,Suzan Lazo,Laura Jardine,David Dixon,Emily Stephenson,Emil Nilsson,Ida Grundberg,David McDonald,Andrew Filby,Weibo Li,Weibo Li,Philip L. De Jager,Philip L. De Jager,Orit Rozenblatt-Rosen,Andrew A. Lane,Andrew A. Lane,Muzlifah Haniffa,Muzlifah Haniffa,Aviv Regev,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +32 more
TL;DR: In this paper, the authors performed single-cell RNA sequencing of ~2400 cells isolated from healthy blood donors and enriched for HLA-DR + lineage − cells, which led them to identify and validate six Dendritic cells (DCs) and four monocyte subtypes.
Journal ArticleDOI
Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses.
Ido Amit,Manuel Garber,Nicolas Chevrier,Ana Paula Leite,Ana Paula Leite,Yoni Donner,Thomas Eisenhaure,Mitchell Guttman,Mitchell Guttman,Jennifer K. Grenier,Weibo Li,Or Zuk,Lisa A. Schubert,Brian Birditt,Tal Shay,Alon Goren,Alon Goren,Xiaolan Zhang,Zachary D. Smith,Raquel P. Deering,Rebecca C. McDonald,Moran N. Cabili,Bradley E. Bernstein,Bradley E. Bernstein,John L. Rinn,Alexander Meissner,David E. Root,Nir Hacohen,Nir Hacohen,Aviv Regev,Aviv Regev,Aviv Regev +31 more
TL;DR: This study establishes a broadly applicable, comprehensive, and unbiased approach to reveal the wiring and functions of a regulatory network controlling a major transcriptional response in primary mammalian cells.
Journal ArticleDOI
Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
Mark Lee,Mark Lee,Chun Ye,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Towfique Raj,Towfique Raj,Towfique Raj,Weibo Li,Weibo Li,Thomas Eisenhaure,Thomas Eisenhaure,Selina Imboywa,Portia Chipendo,F. Ann Ran,Kamil Slowikowski,Lucas D. Ward,Khadir Raddassi,Cristin McCabe,Cristin McCabe,Michelle Lee,Irene Y. Frohlich,David A. Hafler,Manolis Kellis,Soumya Raychaudhuri,Feng Zhang,Feng Zhang,Barbara E. Stranger,Christophe Benoist,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +35 more
TL;DR: In this paper, the effects of genetic variation on the induction of pathogen-responsive genes in human dendritic cells were investigated using a set of 121 common genetic variants associated in cis with variation in expression responses to Escherichia coli lipopolysaccharide, influenza, or interferon-β (IFN-β).
Journal ArticleDOI
IAP inhibitors enhance co-stimulation to promote tumor immunity
Michael Dougan,Stephanie K. Dougan,Joanna Slisz,Brant Firestone,Matthew Vanneman,Dobrin Draganov,Girija Goyal,Weibo Li,Weibo Li,Donna Neuberg,Richard S. Blumberg,Nir Hacohen,Nir Hacohen,Dale Porter,Leigh Zawel,Glenn Dranoff +15 more
TL;DR: It is found that IAP antagonists can augment human and mouse T cell responses to physiologically relevant stimuli and suggest that targeting IAPs using small molecule antagonists may be a strategy for developing novel immunomodulating therapies against cancer.