W
Weidong Wang
Researcher at National Institutes of Health
Publications - 86
Citations - 13635
Weidong Wang is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Chromatin remodeling & FANCM. The author has an hindex of 48, co-authored 78 publications receiving 12895 citations. Previous affiliations of Weidong Wang include VU University Amsterdam & Stanford University.
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Journal ArticleDOI
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
Dongyi Xu,Rong Guo,Alexandra Sobeck,Csanád Z. Bachrati,Jay Yang,Takemi Enomoto,Grant W. Brown,Maureen E. Hoatlin,Ian D. Hickson,Weidong Wang +9 more
TL;DR: A novel component of the BLM complex, RMI2, is reported, which interacts with RMI1 through two oligonucleotide-binding (OB)-fold domains similar to those in RPA, and suggests that multi-OB-fold complexes mediate two modes of BLM action: via RPA-mediated protein-DNA interaction, and via RMI- mediated protein-protein interactions.
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BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
Jinhu Yin,Alexandra Sobeck,Chang Xu,Amom Ruhikanta Meetei,Maureen E. Hoatlin,Lei Li,Weidong Wang +6 more
TL;DR: It is demonstrated that BLAP75, a novel protein containing a putative OB‐fold nucleic acid binding domain, is an integral component of BLM complexes, and is essential for their stability in vivo.
Journal ArticleDOI
Uncovering Early Response of Gene Regulatory Networks in ESCs by Systematic Induction of Transcription Factors
Akira Nishiyama,Li Xin,Alexei A. Sharov,Marshall Thomas,Gregory Mowrer,Emily A. Meyers,Yulan Piao,Samir Mehta,Sarah Yee,Yuhki Nakatake,Carole A. Stagg,Lioudmila V. Sharova,Lina S. Correa-Cerro,Uwem C. Bassey,Hien G. Hoang,Eugene Kim,Richard Tapnio,Yong Qian,Dawood B. Dudekula,Michal Zalzman,Manxiang Li,Geppino Falco,Hsih Te Yang,Sung-Lim Lee,Manuela Monti,Ilaria Stanghellini,Md. Nurul Islam,Ramaiah Nagaraja,Ilya G. Goldberg,Weidong Wang,Dan L. Longo,David Schlessinger,Minoru S.H. Ko +32 more
TL;DR: To examine transcription factor (TF) network(s), mouse ESC lines are created, in each of which 1 of 50 TFs tagged with a FLAG moiety is inserted into a ubiquitously controllable tetracycline-repressible locus, and chIP-Seq revealed that CDX2 binds to promoters of upregulated target genes.
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The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks.
Jing Huang,Shuo Liu,Marina A. Bellani,Arun K. Thazhathveetil,Chen Ling,Johan P. de Winter,Yinsheng Wang,Weidong Wang,Michael M. Seidman +8 more
TL;DR: The results indicate that translocase-based mechanisms enable DNA synthesis to continue past ICLs and that these lesions are not always absolute blocks to replication.
Journal ArticleDOI
Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes.
TL;DR: The cloning of the 57-kDa subunit (BAF57), the first DNA binding subunit for SWI/SNF-like complexes is described and it is suggested that the mechanism by which mammalian and Drosophila SWI-like complex interact with chromatin may involve recognition of higher-order chromatin structure by two or more DNA binding domains.