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Weimin Peng
Researcher at Janssen Pharmaceutica
Publications - 19
Citations - 872
Weimin Peng is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Abiraterone acetate & Prostate cancer. The author has an hindex of 11, co-authored 16 publications receiving 750 citations. Previous affiliations of Weimin Peng include Duke University & University of California, Los Angeles.
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Journal ArticleDOI
Circulating Tumor Cell Biomarker Panel As an Individual-Level Surrogate for Survival in Metastatic Castration-Resistant Prostate Cancer
Howard I. Scher,Glenn Heller,Arturo Molina,Gerhardt Attard,Daniel C. Danila,Xiaoyu Jia,Weimin Peng,Shahneen Sandhu,David Olmos,Ruth Riisnaes,Robert B. McCormack,Tomasz Burzykowski,T. Kheoh,Martin Fleisher,Marc Buyse,Johann S. de Bono +15 more
TL;DR: A biomarker panel containing CTC number and LDH level was shown to be a surrogate for survival at the individual-patient level in this trial of abiraterone acetate plusprednisone versus prednisone alone for patients with metastatic CRPC.
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Intense Androgen-Deprivation Therapy With Abiraterone Acetate Plus Leuprolide Acetate in Patients With Localized High-Risk Prostate Cancer: Results of a Randomized Phase II Neoadjuvant Study
Mary-Ellen Taplin,Bruce Montgomery,Christopher J. Logothetis,Glenn J. Bubley,Jerome P. Richie,Bruce L. Dalkin,Martin G. Sanda,John W. Davis,Massimo Loda,Massimo Loda,Lawrence D. True,Patricia Troncoso,Huihui Ye,Rosina T. Lis,Brett T. Marck,Alvin M. Matsumoto,Steven P. Balk,Elahe A. Mostaghel,Trevor M. Penning,Peter S. Nelson,Wanling Xie,Zhenyang Jiang,C. M. Haqq,Daniel Tamae,Nam Phuong Tran,Weimin Peng,Thian Kheoh,Arturo Molina,Philip W. Kantoff +28 more
TL;DR: Intensive intratumoral androgen suppression with LHRHa plus AA before prostatectomy for localized high-risk PCa may reduce tumor burden.
Journal ArticleDOI
Abiraterone acetate, exemestane or the combination in postmenopausal patients with estrogen receptor-positive metastatic breast cancer
Joyce O'Shaughnessy,M. Campone,Etienne Brain,Patrick Neven,Daniel F. Hayes,Igor Bondarenko,Thomas W. Griffin,Joost Martin,P. De Porre,Thian Kheoh,Margaret K. Yu,Weimin Peng,Stephen R. D. Johnston +12 more
TL;DR: The addition of abiraterone acetate to exemstane did not improve clinical outcomes compared with exemestane alone in an androgen receptor-enriched population, potentially due to induced serum progesterone as a resistance mechanism.
Journal ArticleDOI
The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis.
Mahasen Saleh,Weimin Peng,Mary Ann Quinn-Allen,Sandra Macedo-Ribeiro,Pablo Fuentes-Prior,Wolfram Bode,William H. Kane +6 more
TL;DR: It is concluded that solvent exposed hydrophobic and aromatic amino acids in both f Va-C1 and fVa-C2 contribute to the interaction of factor V with PS membranes.
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Regulators of Cellular Levels of Histone Acetylation in Saccharomyces cerevisiae
TL;DR: It is shown that Gcn5, a major HAT in yeast, has diminished histone acetyltransferase activity in particular mutants, providing a plausible explanation for reduction of cellular acetylation levels in vivo.