다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

Universal sample preparation method for proteome analysis

From a Novel

Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy by regulating the tumor microenvironment (TME) and to highlight the potential of hypoxia-targeted therapy. Relevant published studies were retrieved from PubMed, Web of Science, and Embase using keywords such as hypoxia, cancer therapy, resistance, TME, cancer, apoptosis, DNA damage, autophagy, p53, and other similar terms. Recent studies have shown that hypoxia is associated with poor prognosis in patients by regulating the TME. It confers resistance to conventional therapies through a number of signaling pathways in apoptosis, autophagy, DNA damage, mitochondrial activity, p53, and drug efflux. Hypoxia targeting might be relevant to overcome hypoxia-associated resistance in cancer treatment.

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Role of hypoxia in cancer therapy by regulating the tumor microenvironment

[This corrects the article on p. 843 in vol. 6, PMID: 27186435.].

Erratum: In vitro and in vivo antiangiogenic activity of desacetylvinblastine monohydrazide through inhibition of VEGFR2 and Axl pathways.

Leptosperols C−G (1–5), five new phenylpropanoyl phloroglucinol derivatives were isolated from the leaves of Leptospermum scoparium. Compounds 1–3 are phenylpropanoyl phloroglucinol‐sesquiterpene adducts with new carbon skeletons. Their structures with absolute configurations were elucidated by detailed spectroscopic analyses, single‐crystal X‐ray diffraction, and electronic circular dichroism (ECD) calculation. Compounds 2 and 3 exhibited moderate anti‐inflammatory activity in zebrafish acute inflammatory models.

Five New Phenylpropanoyl Phloroglucinol Derivatives from Leptospermum scoparium

The invention discloses an application of a vinca alkaloid derivative in preparation of a medicine for inhibiting tumor metastasis. The vinca alkaloid derivative comprises vinca alkaloid dipeptide and physically-acceptable salt of the vinca alkaloid dipeptide. The vinca alkaloid dipeptide is a compound formed by condensation of a hydrazinolysis vinca alkaloid compound and N-carbobenzoxy-dipeptide. The hydrazinolysis vinca alkaloid compound is a compound obtained by reacting of a vinca alkaloid compound and a hydrazine hydrate. The vinca alkaloid compound is vinblastine, or vinorelbine, or vinflunine or vincristine. Through the vinca alkaloid dipeptide and the physically-acceptable salt of the vinca alkaloid dipeptide, invasion, transferring and horizontal movement capability of tumor cells can be significantly inhibited in vitro, the distant metastasis of a tumor is significantly inhibited in vivo, and thus the vinca alkaloid derivative can be applied to treatment of a patient with the advanced malignant tumor along with the distant metastasis.

Wen-Cai Ye

Papers

Erratum: In vitro and in vivo antiangiogenic activity of desacetylvinblastine monohydrazide through inhibition of VEGFR2 and Axl pathways.

Five New Phenylpropanoyl Phloroglucinol Derivatives from Leptospermum scoparium

Application of vinca alkaloid derivative in preparation of medicine for inhibiting tumor metastasis

Eugenilones A-N: Sesquiterpenoids from the fruits of Eugenia uniflora.

Medicinal Angiosperms of Solanaceae