다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

Universal sample preparation method for proteome analysis

From a Novel

Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy by regulating the tumor microenvironment (TME) and to highlight the potential of hypoxia-targeted therapy. Relevant published studies were retrieved from PubMed, Web of Science, and Embase using keywords such as hypoxia, cancer therapy, resistance, TME, cancer, apoptosis, DNA damage, autophagy, p53, and other similar terms. Recent studies have shown that hypoxia is associated with poor prognosis in patients by regulating the TME. It confers resistance to conventional therapies through a number of signaling pathways in apoptosis, autophagy, DNA damage, mitochondrial activity, p53, and drug efflux. Hypoxia targeting might be relevant to overcome hypoxia-associated resistance in cancer treatment.

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Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Psychotria sp. extract, and preparation method and antineoplastic application thereof

For detecting polyhydroxyalkaloids-type alpha-glucosidase-inhibiting ingredients of Commelina communis L grown in China, total alkaloids were obtained from the plant by extraction with water, removal of precipitation after the addition of alcohol, enrichment and purification by ion exchange resin and sephadex LH 20 chromatography Polyhydroxyalkaloids in the total alkaloids were detected by ion trap electron-spray ionization mass spectra (ESIMS) Several reported and unreported polyhydroxyalkaloids in the plant were detected from the material collected from Jixi county, Anhui province The crude drug growing in China contains alpha-glucosidase-inhibiting polyhydroxyalkaloids and can be used to therapy in diabetes

[Detection for alpha-glucosidase-inhibiting polyhydroxyalkaloid ingredients of Commelina communis L. by ESIMS].

Objective To study the chemical constituents of Gekko swinhonis. Method The compounds were isolated and purified by several column chromatographic methods with silica gel, ODS, Sephadex LH-20 and preparative HPLC, Their structures were identified by physicochemical properties and spectral data. Result Thirteen compounds were isolated and elucidated as cyclo-(Pro-Leu) (1), cyclo-(Ala-Pro) (2),cyclo-(Gly-Pro) (3),cyclo-(Ala-Val) (4),6-amino-9-beta-D-ribofuranosyl-9H-purine (5), uridine (6), thymidine (7),hypoxanthine-9-beta-D-ribofuranosid (8),L-phenylalanine (9),5alpha-cholest-3,6-dione (10),cholesterol (11), 1-O-hexadecanolenin (12),octadecanoic acid (13),respectively. Conclusion All compounds were isolated from G. swinhonis for the first time.

Chemical constituents of Gekko swinhonis

AIM To investigate the chemical constituents from the rhizomes of Cimicifuga acerina (Sieb et Zucc) Tanaka METHODS Column chromatgraphy (including silica gel and ODS) together with HPLC was used to separate the chemical constituents whose structures were determined by FAB-MS, NMR (1D and 2D) and hydrolysis methods RESULTS Five cycloartane triterpenoids were isolated and identified as: (22R)-22-hydroxycimigenol (I), (22R)-22-hydroxy-24- O -acetylhydroshengmanol 3- O -β- D -xylopyranoside (II), dahurinol (III), 24- epi -24- O -acetyl-7,8-didehydroshengmanol 3- O -β- D -xylopyranoside (IV), 25- O -acetyl-7,8-didehydrocimigenol 3- O -β- D -xylopyranoside (V) CONCLUSION Compound I is a new natural product, compound II is a new compound and compounds IV and V were isolated from this plant for the first time

Cycloartane triterpenes and glycosides from Cimicifuga acerina

Myrtucyclitones A-C ((+)- and (-)-1-3), three pairs of new triketone-phloroglucinol-triketone hybrids were isolated from the plant Myrtus communis. Their structures with absolute configurations were established by NMR analysis and chemical calculations. Myrtucyclitones B and C exhibited remarkable antibacterial effect.

Wen-Cai Ye

Papers

Psychotria sp. extract, and preparation method and antineoplastic application thereof

[Detection for alpha-glucosidase-inhibiting polyhydroxyalkaloid ingredients of Commelina communis L. by ESIMS].

Chemical constituents of Gekko swinhonis

Cycloartane triterpenes and glycosides from Cimicifuga acerina

Antibacterial Triketone‐Phloroglucinol‐Triketone Adducts from Myrtus communis