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Wen-Cai Ye
Researcher at Jinan University
Publications - 551
Citations - 10678
Wen-Cai Ye is an academic researcher from Jinan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 41, co-authored 485 publications receiving 7917 citations. Previous affiliations of Wen-Cai Ye include Chinese Ministry of Education & Second Military Medical University.
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Journal ArticleDOI
New structures, chemotaxonomic significance and COX-2 inhibitory activities of cassane-type diterpenoids from the seeds of Caesalpinia minax
Jian-Long Zhang,Jian-Long Zhang,Zhi-Hua Chen,Jun Xu,Juan Li,Ya-Fang Tan,Ju-Hua Zhou,Wen-Cai Ye,Hai-Yan Tian,Ren-Wang Jiang +9 more
TL;DR: In this paper, 11 cassane-type diterpenoids (1-11) along with 12 known compounds were isolated from the seeds of Caesalpinia minax Hance and their structures were determined by extensive spectroscopic methods in combination with X-ray diffraction analysis.
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Antiproliferative triterpenoid saponins from the stem of Psychotria sp.
Cui-Xian Zhang,Dong-Mei Zhang,Minfeng Chen,Shan-Yue Guan,Jun-Hua Yao,Xi-Xin He,Ling-Fang Lei,Ying Zhong,Zhi-fang Wang,Wen-Cai Ye +9 more
TL;DR: Psychotrianoside C (3) showed the most potent antiproliferative activity among these saponins, and the IC50 value of 3 against MDA-MB-231 was 2.391 ± 0.161 µM, which was also found to induce apoptosis.
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Uncoupling of K+ and Cl− transport across the cell membrane in the process of regulatory volume decrease
TL;DR: It is proved that K(+) and Cl(-) transport mainly by channels in RVD was uncoupled in nasopharyngeal carcinoma CNE-2Z cells, and H(+) efflux may play important roles in cell volume regulation, and may be a therapeutic target for human nasoph throat carcinoma.
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C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells
Zhi Qi Yin,Shu Le Yu,Yu Jian Wei,Lin Ma,Zheng Feng Wu,Lei Wang,Qing-Wen Zhang,Ming Zhao,Wen-Cai Ye,Chun-Tao Che,Jian Zhang +10 more
TL;DR: Results indicated that compound 4 might be valuable to anticancer drug candidates because it could induce G1 phase arrest, upregulate the expression levels of caspases-3, -9, and Bax, and downregulates the expression level of Bcl-2.
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Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer.
Huan Long,Xiao-Long Hu,Baolin Wang,Quan Wang,Rong Wang,Shumeng Liu,Fei Xiong,Zhenzhou Jiang,Xiao-Qi Zhang,Wen-Cai Ye,Hao Wang +10 more
TL;DR: In this paper, the PARP-1 inhibitor 15l·2HCl has been shown to be a potential target for the discovery of chemosensitizers and anticancer drugs and showed a potent chemotherapy sensitizing effect against A549 cells and a selective cytotoxic effect toward SK-OV-3 cells.