다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

Universal sample preparation method for proteome analysis

From a Novel

Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy by regulating the tumor microenvironment (TME) and to highlight the potential of hypoxia-targeted therapy. Relevant published studies were retrieved from PubMed, Web of Science, and Embase using keywords such as hypoxia, cancer therapy, resistance, TME, cancer, apoptosis, DNA damage, autophagy, p53, and other similar terms. Recent studies have shown that hypoxia is associated with poor prognosis in patients by regulating the TME. It confers resistance to conventional therapies through a number of signaling pathways in apoptosis, autophagy, DNA damage, mitochondrial activity, p53, and drug efflux. Hypoxia targeting might be relevant to overcome hypoxia-associated resistance in cancer treatment.

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Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Two new sesquiterpene lactones from the supercritical fluid extract of Centipeda minima.

Caffeic acid oligomers from Mesona chinensis and their In Vitro antiviral activities.

A new amide and a new monoterpene from the seeds of Clausena lansium.

Three new phenylpropanoid-substituted epicatechin glycosides, namely parabarosides A - C ( 1- 3), together with three known compounds, 5-caffeoylquinic acid ( 4), 5-caffeoylshikimic acid ( 5), and 3,4-dicaffeoylquinic acid ( 6), were obtained from the plant PARABARIUM HUAITINGII. Their structures were determined and full assignments of 1 H- and 13 C-NMR spectroscopic data were achieved by analyses of 1D- and 2D-NMR, mass, and CD spectra. The oxygen radical absorbance capacity (ORAC) assay was applied to evaluate their antioxidative capacity IN VITRO, which revealed that 1- 6 showed strong antioxidative properties.

Antioxidative phenylpropanoid-substituted epicatechin glycosides from Parabarium huaitingii.

Three new monoterpenoid indole alkaloids (MIAs), hunterines A-C (1-3), were isolated from Hunteria zeylanica. Compound 1 possesses a unique skeleton with an unprecedented azabicyclo[4.3.1]decane ring system. Compounds 2 and 3 are a pair of epimeric vobasinylindole alkaloid heterodimers. Their structures including absolute configurations were established by spectroscopic analyses, X-ray diffraction, computational calculation, and the modified Mosher's method. Plausible biogenetic pathways of 1-3 were also proposed. Alkaloid 1 showed moderate cytotoxic activity against the HepG2 cell line.

Wen-Cai Ye

Papers

Two new sesquiterpene lactones from the supercritical fluid extract of Centipeda minima.

Caffeic acid oligomers from Mesona chinensis and their In Vitro antiviral activities.

A new amide and a new monoterpene from the seeds of Clausena lansium.

Antioxidative phenylpropanoid-substituted epicatechin glycosides from Parabarium huaitingii.

Hunterines A–C, Three Unusual Monoterpenoid Indole Alkaloids from Hunteria zeylanica