W
Wenda Gao
Researcher at Beth Israel Deaconess Medical Center
Publications - 99
Citations - 17909
Wenda Gao is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Interleukin 21 & FOXP3. The author has an hindex of 41, co-authored 89 publications receiving 16636 citations. Previous affiliations of Wenda Gao include Tufts University & Third Military Medical University.
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Journal ArticleDOI
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
Journal ArticleDOI
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
TL;DR: It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
Journal ArticleDOI
IL-21 initiates an alternative pathway to induce proinflammatory T H 17 cells
Thomas Korn,Estelle Bettelli,Wenda Gao,Amit Awasthi,Anneli Jäger,Terry B. Strom,Mohamed Oukka,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6-deficient (Il6-/-) mice do not develop a TH17 response and their peripheral repertoire is dominated by Foxp3+ Treg cells, suggesting an additional pathway by which TH17 cells might be generated in vivo.
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IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells
Valerie Dardalhon,Amit Awasthi,Hyoung-Joon Kwon,George Galileos,Wenda Gao,Raymond A. Sobel,Meike Mitsdoerffer,Terry B. Strom,Wassim Elyaman,I-Cheng Ho,Samia J. Khoury,Mohamed Oukka,Vijay K. Kuchroo +12 more
TL;DR: The authors showed that IL-4 blocked the generation of TGF-beta-induced Foxp3(+) T(reg) cells and instead induced a population of T helper cells that produced IL-9 and IL-10.
Journal ArticleDOI
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
Thomas Korn,Jayagopala Reddy,Wenda Gao,Estelle Bettelli,Amit Awasthi,Troels R. Petersen,B Thomas Bäckström,Raymond A. Sobel,Raymond A. Sobel,Kai W. Wucherpfennig,Terry B. Strom,Mohamed Oukka,Vijay K. Kuchroo +12 more
TL;DR: The data suggest that in order for CD4+Foxp3+ T-reg to effectively control autoimmune reactions in the target organ, it may also be necessary to control tissue inflammation.