Wenfu Lu

TL;DR: It is reported that p19Arf (p14ARF in human) stabilizes Slug to inhibit E‐cadherin in prostate cancer mouse models, demonstrating that ARF has dual tumor suppressive/oncogenic roles in cancers in a context‐dependent manner.

TL;DR: New insights about molecular mechanisms on ubiquitination and SUMOylation are discussed, their associations with diseases, oncogenic impact on prostate cancer (PCa) and clinical implications for PCa treatment are discussed.

TL;DR: It is reported that Skp2 modulates JARID1B and H3K4me3 levels in vitro in cultured cells and in vivo in mouse models, and the findings reveal a novel network of SKP2- JARIDs1B, and targeting SKp2 and JARid1B may be a potential strategy for PCa control.

TL;DR: It is reported that EZH2 is post-transcriptionally regulated by SKP2 in vitro in cultured cells and in vivo in mouse models, and a concurrent elevation of Skp2 and Ezh2 was found in CRPC tumors of Pten/Trp53 mutant mice, and expression levels ofSKP2 and EZh2 were positively correlated in human PCa specimens.

TL;DR: The SirT6-dependent cysteine monoubiquitination of the histone methyltransferase Suv39h1 is described as part of a regulatory circuit for the NF-κB pathway, which regulates the regulation of responses to diverse types of cellular stress.