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Will Liao
Researcher at Stony Brook University
Publications - 28
Citations - 2956
Will Liao is an academic researcher from Stony Brook University. The author has contributed to research in topics: Gene & Transcription factor. The author has an hindex of 12, co-authored 20 publications receiving 2244 citations. Previous affiliations of Will Liao include Cold Spring Harbor Laboratory & Hoffmann-La Roche.
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Journal ArticleDOI
The cellular and molecular origin of tumor-associated macrophages.
Ruth A. Franklin,Will Liao,Abira Sarkar,Myoungjoo V. Kim,Myoungjoo V. Kim,Michael R. Bivona,Kang Liu,Eric G. Pamer,Ming O. Li +8 more
TL;DR: In mice, mammary tumor growth induces the accumulation of tumor-associated macrophage that are phenotypically and functionally distinct from mammary tissue macrophages, which reveal the ontogeny of TAMs and a discrete tumor-elicited inflammatory response, which may provide new opportunities for cancer immunotherapy.
Journal ArticleDOI
Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification
Robert M. Samstein,Aaron Arvey,Steven Z. Josefowicz,Xiao Peng,Alex Reynolds,Richard Sandstrom,Shane Neph,Peter J. Sabo,Jeong M. Kim,Will Liao,Ming O. Li,Christina S. Leslie,John A. Stamatoyannopoulos,Alexander Y. Rudensky +13 more
TL;DR: In a late cellular differentiation process, Foxp3 defines Treg cell functionality in an "opportunistic" manner by largely exploiting the preformed enhancer network instead of establishing a new enhancer landscape.
Journal ArticleDOI
Novel Foxo1-dependent transcriptional programs control T reg cell function
Weiming Ouyang,Will Liao,Will Liao,Chong T. Luo,Na Yin,Morgan Huse,Myoungjoo V. Kim,Min Peng,Pamela Chan,Qian Ma,Yifan Mo,Yifan Mo,Dies Meijer,Keji Zhao,Alexander Y. Rudensky,Gurinder S. Atwal,Michael Q. Zhang,Michael Q. Zhang,Ming O. Li +18 more
TL;DR: Findings show that the evolutionarily ancient Akt–Foxo1 signalling module controls a novel genetic program indispensable for Treg cell function.
Journal ArticleDOI
Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.
Asaf Zviran,Rafael C. Schulman,Minita Shah,Steven T. K. Hill,Sunil Deochand,Cole C. Khamnei,Dillon Maloney,Kristofer Patel,Will Liao,Adam J. Widman,Adam J. Widman,Phillip Wong,Margaret K. Callahan,Gavin Ha,Sarah C. Reed,Denisse Rotem,Dennie T. Frederick,Tatyana Sharova,Benchun Miao,Tommy Kim,Greg Gydush,Justin Rhoades,Kevin Y. Huang,Nathaniel D. Omans,Patrick O. Bolan,Andrew Lipsky,Chelston Ang,Murtaza Malbari,Catherine F. Spinelli,Selena Kazancioglu,Alexi M. Runnels,Samantha Fennessey,Christian Stolte,Federico Gaiti,Giorgio Inghirami,Viktor A. Adalsteinsson,Brian Houck-Loomis,Jennifer Ishii,Jedd D. Wolchok,Genevieve M. Boland,Nicolas Robine,Nasser K. Altorki,Dan A. Landau +42 more
TL;DR: An orthogonal framework for cfDNA cancer monitoring via genome-wide mutational integration is presented, enabling ultra-sensitive detection, overcoming the limitation of cfDNA abundance and empowering treatment optimization in low-disease-burden oncology care.
Journal ArticleDOI
The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection
Myoungjoo V. Kim,Weiming Ouyang,Will Liao,Will Liao,Michael Q. Zhang,Michael Q. Zhang,Ming O. Li,Ming O. Li +7 more
TL;DR: It is shown that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection.