William K. Gottschalk

TL;DR: The effects of the potent, tyrosine-based PPARγ ligand GW1929 on serum glucose and lipid parameters and gene expression in Zucker diabetic fatty rats are characterized and a comprehensive and unbiased messenger RNA profiling technique is used to identify genes regulated either directly or indirectly by PParγ in epididymal white adipose tissue, interscapular brown adipose tissues, liver, and soleus skeletal muscle.

TL;DR: A genome-wide association study of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians suggests protective mechanisms including immunity and nutrient metabolism and their interactions with environmental stress play key roles in human longevity.

TL;DR: The genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40‐kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late‐onset Alzheimer's disease (LOAD) is investigated to determine whether a highly polymorphic, intronic poly‐T within this region affects expression of the APOE and TOMM40 genes.

TL;DR: The TOM40-mediated mitochondrial protein import mechanism is described, and the evidence linking TOM40 with Alzheimer's (AD) and Parkinson's (PD) diseases is discussed, and new targets for preventative and/or therapeutic treatments are discussed.

TL;DR: A composite genetic biomarker is presented to stratify disease risk so as to facilitate clinical studies in high‐risk populations and the rationale for the use of pioglitazone to delay the onset of AD in individuals at high risk is discussed.