A
Anatoliy I. Yashin
Researcher at Duke University
Publications - 116
Citations - 1962
Anatoliy I. Yashin is an academic researcher from Duke University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 22, co-authored 116 publications receiving 1543 citations. Previous affiliations of Anatoliy I. Yashin include Durham University & Population Research Institute.
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Journal ArticleDOI
Novel loci and pathways significantly associated with longevity
Yi Zeng,Yi Zeng,Chao Nie,Junxia Min,Xiaomin Liu,Mengmeng Li,Huashuai Chen,Huashuai Chen,Hanshi Xu,Mingbang Wang,Ting Ni,Yang Li,Han Yan,Jin Pei Zhang,Chun Song,Li Qing Chi,Han Ming Wang,Jie Dong,Gu Yan Zheng,Li Lin,Feng Qian,Yanwei Qi,Xiao Liu,Hongzhi Cao,Yinghao Wang,Lijuan Zhang,Zhaochun Li,Yufeng Zhou,Yan Wang,Jiehua Lu,Jianxin Li,Ming Qi,Lars Bolund,Anatoliy I. Yashin,Kenneth C. Land,Simon G. Gregory,Ze Yang,William K. Gottschalk,Wei Tao,Jian Wang,Jun Wang,Xun Xu,Harold Bae,Marianne Nygaard,Lene Christiansen,Kaare Christensen,Claudio Franceschi,Michael W. Lutz,Jun Gu,Qihua Tan,Thomas T. Perls,Paola Sebastiani,Joris Deelen,Eline Slagboom,Elizabeth R. Hauser,Huji Xu,Xiao-Li Tian,Huanming Yang,James W. Vaupel +58 more
TL;DR: A genome-wide association study of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians suggests protective mechanisms including immunity and nutrient metabolism and their interactions with environmental stress play key roles in human longevity.
Journal ArticleDOI
Joint influence of small-effect genetic variants on human longevity
TL;DR: The results of this study strongly suggest that the alleles with small individual effects on longevity may jointly influence life span so that the resulting influence can be both substantial and significant.
Journal ArticleDOI
Telomeres and the natural lifespan limit in humans.
Troels Steenstrup,Jeremy D. Kark,Simon Verhulst,Mikael Thinggaard,Jacob v. B. Hjelmborg,Christine Dalgård,Kirsten Ohm Kyvik,Lene Christiansen,Massimo Mangino,Massimo Mangino,Tim D. Spector,Inge Petersen,Masayuki Kimura,Athanase Benetos,Athanase Benetos,Carlos Labat,Carlos Labat,Ronit Sinnreich,Shih-Jen Hwang,Daniel Levy,Steven C. Hunt,Annette L. Fitzpatrick,Wei Chen,Gerald S. Berenson,Michelangela Barbieri,Giuseppe Paolisso,Shahinaz M. Gadalla,Sharon A. Savage,Kaare Christensen,Anatoliy I. Yashin,Konstantin G. Arbeev,Abraham Aviv +31 more
TL;DR: It is shown that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy, which means secular trends in life expectancy should confront a biological limit due to crossing the telomersic brink.
Journal ArticleDOI
Age patterns of incidence of geriatric disease in the U.S. elderly population: Medicare-based analysis.
Igor Akushevich,Julia Kravchenko,Svetlana V. Ukraintseva,Konstantin G. Arbeev,Anatoliy I. Yashin +4 more
TL;DR: To use the Medicare Files of Service Use (MFSU) to evaluate patterns in the incidence of aging‐related diseases in the U.S. elderly population, Medicare files of service use are used.
Journal ArticleDOI
Age trajectories of physiological indices in relation to healthy life course.
Konstantin G. Arbeev,Svetlana V. Ukraintseva,Igor Akushevich,Alexander M. Kulminski,Liubov S. Arbeeva,Lucy Akushevich,Irina Culminskaya,Anatoliy I. Yashin +7 more
TL;DR: The results indicate the presence of substantial gender difference in aging related decline in stress resistance and adaptive capacity, which can contribute to differences in the shape of the sex-specific patterns of incidence rates of aging related diseases.