Han Yan

TL;DR: A genome-wide association study of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians suggests protective mechanisms including immunity and nutrient metabolism and their interactions with environmental stress play key roles in human longevity.

TL;DR: The results underscore the importance and potential of larger reference panels to impute rare variants, while recognizing that increasing ethnic specific variants in reference panels may result in better imputation for genotypes in some ethnic groups.

TL;DR: It is shown that 2 genes, SCML4 and THSD7A, make functional contributions to atherosclerosis and how rs852787 and its host gene DAB1 are linked to CAD needs further studies.

TL;DR: Functional analysis showed that NEXN promotes VSMC to a contractile phenotype in vitro and inhibits balloon-injury induced neointima formation in vivo, and eQTL analysis demonstrated that the risk allele T of rs1780050 is associated with decreased expression of NEXn, thus contributing to a higher risk of CAD susceptibility in the population.

TL;DR: It is suggested that AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism and inhibited the mTOR pathway and the protein ubiquitination process.