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Xi Ping Huang
Researcher at University of North Carolina at Chapel Hill
Publications - 102
Citations - 17170
Xi Ping Huang is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 50, co-authored 102 publications receiving 13223 citations. Previous affiliations of Xi Ping Huang include National Institutes of Health & Commonwealth Scientific and Industrial Research Organisation.
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Journal ArticleDOI
Structural Features for Functional Selectivity at Serotonin Receptors
Daniel Wacker,Chong Wang,Vsevolod Katritch,Gye Won Han,Xi Ping Huang,Eyal Vardy,John D. McCorvy,Yi Jiang,Yi Jiang,Meihua Chu,Fai Yiu Siu,Wei Liu,H. Eric Xu,Vadim Cherezov,Bryan L. Roth,Raymond C. Stevens +15 more
TL;DR: Biochemical studies showing that the hallucinogen lysergic acid diethylamide, its precursor ergotamine (ERG), and related ergolines display strong functional selectivity for β-arrestin signaling at the 5-HT2B 5-hydroxytryptamine (5-HT) receptor, whereas they are relatively unbiased at the 4-HT1B receptor are reported.
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PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
Wesley K. Kroeze,Maria F. Sassano,Xi Ping Huang,Katherine Lansu,John D. McCorvy,Patrick M. Giguère,Noah Sciaky,Bryan L. Roth +7 more
TL;DR: A unique open-source resource is described that allows interrogation of the druggable human GPCRome via a G protein–independent β-arrestin–recruitment assay and its utility for discovering new ligands for orphanhuman GPCRs is demonstrated.
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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Masoud Vedadi,Dalia Barsyte-Lovejoy,Feng Liu,Sylvie Rival-Gervier,Abdellah Allali-Hassani,Viviane Labrie,Tim J. Wigle,Peter A. DiMaggio,Gregory A. Wasney,Alena Siarheyeva,Aiping Dong,Wolfram Tempel,Sun Chong Wang,Sun Chong Wang,Xin Chen,Irene Chau,Thomas J. Mangano,Xi Ping Huang,Catherine Simpson,Samantha G. Pattenden,Jacqueline L. Norris,Dmitri Kireev,Ashutosh Tripathy,Aled M. Edwards,Bryan L. Roth,William P. Janzen,Benjamin A. Garcia,Arturas Petronis,James Ellis,Peter Brown,Stephen V. Frye,Cheryl H. Arrowsmith,Jian Jin +32 more
TL;DR: UNC0638 is reported, an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets, and markedly reduced the clonogenicity of MCF7 cells and disproportionately affected several genomic loci encoding microRNAs.
Journal ArticleDOI
Structural Basis for Molecular Recognition at Serotonin Receptors
Chong Wang,Yi Jiang,Yi Jiang,Jinming Ma,Jinming Ma,Huixian Wu,Daniel Wacker,Vsevolod Katritch,Gye Won Han,Wei Liu,Xi Ping Huang,Eyal Vardy,John D. McCorvy,Xiang Gao,X. Edward Zhou,Karsten Melcher,Chenghai Zhang,Fang Bai,Huaiyu Yang,Linlin Yang,Hualiang Jiang,Bryan L. Roth,Vadim Cherezov,Raymond C. Stevens,H. Eric Xu +24 more
TL;DR: Crystal structures of the human 5-HT1B G protein–coupled receptor bound to the agonist antimigraine medications ergotamine and dihydroergotamine are reported and provide a comprehensive structural basis for understanding receptor-ligand interactions and designing subtype-selective serotonergic drugs.
Journal ArticleDOI
Structure of the human smoothened receptor bound to an antitumour agent
Chong Wang,Huixian Wu,Vsevolod Katritch,Gye Won Han,Xi Ping Huang,Wei Liu,Fai Yiu Siu,Bryan L. Roth,Vadim Cherezov,Raymond C. Stevens +9 more
TL;DR: Although the SMO receptor shares the seven-transmembrane helical fold, most of the conserved motifs for class A GPCRs are absent, and the structure reveals an unusually complex arrangement of long extracellular loops stabilized by four disulphide bonds.