C
Chenghai Zhang
Researcher at Chinese Academy of Sciences
Publications - 15
Citations - 1705
Chenghai Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Affinity chromatography & Medicine. The author has an hindex of 9, co-authored 12 publications receiving 1491 citations. Previous affiliations of Chenghai Zhang include Van Andel Institute.
Papers
More filters
Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
Structural Basis for Molecular Recognition at Serotonin Receptors
Chong Wang,Yi Jiang,Yi Jiang,Jinming Ma,Jinming Ma,Huixian Wu,Daniel Wacker,Vsevolod Katritch,Gye Won Han,Wei Liu,Xi Ping Huang,Eyal Vardy,John D. McCorvy,Xiang Gao,X. Edward Zhou,Karsten Melcher,Chenghai Zhang,Fang Bai,Huaiyu Yang,Linlin Yang,Hualiang Jiang,Bryan L. Roth,Vadim Cherezov,Raymond C. Stevens,H. Eric Xu +24 more
TL;DR: Crystal structures of the human 5-HT1B G protein–coupled receptor bound to the agonist antimigraine medications ergotamine and dihydroergotamine are reported and provide a comprehensive structural basis for understanding receptor-ligand interactions and designing subtype-selective serotonergic drugs.
Journal ArticleDOI
Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14
Lihua Zhao,X. Edward Zhou,Wu Zhongshan,Wu Zhongshan,Wei Yi,Yong Xu,Yong Xu,Suling Li,Ting-Hai Xu,Yue Liu,Run-Ze Chen,Amanda Kovach,Yangyong Kang,Li Hou,Li Hou,Yuanzheng He,Cen Xie,Wanling Song,Dafang Zhong,Yechun Xu,Yonghong Wang,Jiayang Li,Chenghai Zhang,Karsten Melcher,H. Eric Xu,H. Eric Xu +25 more
TL;DR: Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-Signaling DWARF14 are presented.
Journal ArticleDOI
Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol.
Kelly Suino-Powell,Yong Xu,Chenghai Zhang,Yongguang Tao,W. David Tolbert,S. Stoney Simons,H. Eric Xu +6 more
TL;DR: It is reported that the ligand pocket of glucocorticoid receptor (GR) can be continuously extended into the top half of the LBD by binding to deacylcortivazol (DAC), an extremely potent glucoc Corticoid.
Journal ArticleDOI
Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response
Yuanzheng He,Yong Xu,Chenghai Zhang,Xiang Gao,Karl Dykema,Katie R. Martin,Jiyuan Ke,Eric Hudson,Sok Kean Khoo,James H. Resau,Arthur S. Alberts,Jeffrey P. MacKeigan,Kyle A. Furge,H. Eric Xu,H. Eric Xu +14 more
TL;DR: It is shown that glucocorticoid signaling is regulated by lysosomes, which provides a mechanistic basis for treating inflammation and autoimmune diseases with a combination of glucoc Corticoids and lysOSomal inhibitors.