V
Viviane Labrie
Researcher at Van Andel Institute
Publications - 52
Citations - 3231
Viviane Labrie is an academic researcher from Van Andel Institute. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 22, co-authored 49 publications receiving 2616 citations. Previous affiliations of Viviane Labrie include Michigan State University & Sunnybrook Health Sciences Centre.
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Journal ArticleDOI
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Masoud Vedadi,Dalia Barsyte-Lovejoy,Feng Liu,Sylvie Rival-Gervier,Abdellah Allali-Hassani,Viviane Labrie,Tim J. Wigle,Peter A. DiMaggio,Gregory A. Wasney,Alena Siarheyeva,Aiping Dong,Wolfram Tempel,Sun Chong Wang,Sun Chong Wang,Xin Chen,Irene Chau,Thomas J. Mangano,Xi Ping Huang,Catherine Simpson,Samantha G. Pattenden,Jacqueline L. Norris,Dmitri Kireev,Ashutosh Tripathy,Aled M. Edwards,Bryan L. Roth,William P. Janzen,Benjamin A. Garcia,Arturas Petronis,James Ellis,Peter Brown,Stephen V. Frye,Cheryl H. Arrowsmith,Jian Jin +32 more
TL;DR: UNC0638 is reported, an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets, and markedly reduced the clonogenicity of MCF7 cells and disproportionately affected several genomic loci encoding microRNAs.
Journal ArticleDOI
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.
Tarang Khare,Shraddha Pai,Karolis Koncevičius,Karolis Koncevičius,Mrinal Pal,Edita Kriukiene,Zita Liutkeviciute,Manuel Irimia,Peixin Jia,Carolyn Ptak,Menghang Xia,Raymond R. Tice,Mamoru Tochigi,Solange Moréra,Anaies Nazarians,Denise D. Belsham,Albert H.C. Wong,Benjamin J. Blencowe,Sun Chong Wang,Sun Chong Wang,Philipp Kapranov,Rafal Kustra,Viviane Labrie,Saulius Klimašauskas,Arturas Petronis +24 more
TL;DR: A new role for 5-hmC in RNA splicing and synaptic function in the brain is suggested as well as substantial tissue-specific differential distributions of these DNA modifications at the exon-intron boundary in human and mouse tissues.
Journal ArticleDOI
Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis
TL;DR: It is hypothesized that Parkinson's disease pathogenesis can be divided into three temporal phases and clinical trials need to consider these three phases and target potential therapies at the appropriate stage of the disease process in order to be effective.
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The vermiform appendix impacts the risk of developing Parkinson’s disease
Bryan A. Killinger,Zachary Madaj,Jacek Sikora,Nolwen L. Rey,Nolwen L. Rey,Alec J. Haas,Yamini Vepa,Daniel Lindqvist,Honglei Chen,Paul M. Thomas,Patrik Brundin,Lena Brundin,Viviane Labrie,Viviane Labrie +13 more
TL;DR: It is proposed that the normal human appendix contains pathogenic forms of α-synuclein that affect the risk of developing Parkinson’s disease.
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Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
Viviane Labrie,Ryutaro Fukumura,Anjali Rastogi,Laura J. Fick,Wei Wang,Paul C. Boutros,James L. Kennedy,Mawahib O. Semeralul,Frankie H. F. Lee,Glen B. Baker,Denise D. Belsham,Steven W. Barger,Yoichi Gondo,Albert H.C. Wong,John C. Roder +14 more
TL;DR: Analysis of SRR genetic variants in humans identified a robust association with schizophrenia and demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis.