Xiang Lin

TL;DR: Targeted disruption of Paneth cell lysozyme (Lyz1) protected mice from experimental colitis and balances intestinal anti- and pro-inflammatory responses, with implications for IBD.

TL;DR: This paper performed genomic analysis of tumor tissue from recurrent WHO grade IV glioblastoma patients acquired prior to immunotherapy intervention and reported that very low tumor mutation burden is associated with longer survival after recombinant polio virotherapy or after immune checkpoint blockade in recurrent glioblastic tumor patients.

TL;DR: Wang et al. as discussed by the authors proposed a principled clustering method named scDCC, which integrates domain knowledge into the clustering step to facilitate the biological interpretability of clusters, and subsequent cell type identification.

TL;DR: Wang et al. as discussed by the authors developed a multimodal deep learning method, scMDC, for single-cell multi-omics data clustering analysis, which is an end-to-end deep model that explicitly characterizes different data sources and jointly learns latent features of deep embedding.

TL;DR: In this article, the authors used pan-pathogen microarray (PathoChip) to determine the bacterial microbiome in patients with Oropharyngeal squamous cell carcinoma (OPSCC) and compared them to benign tonsil specimens.