F
Frederick S. Varn
Researcher at Dartmouth College
Publications - 53
Citations - 1541
Frederick S. Varn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Glioma & Tumor microenvironment. The author has an hindex of 14, co-authored 40 publications receiving 733 citations.
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Journal ArticleDOI
Longitudinal molecular trajectories of diffuse glioma in adults
Floris P. Barthel,Kevin C. Johnson,Frederick S. Varn,Anzhela D. Moskalik,Georgette Tanner,Emre Kocakavuk,Kevin J. Anderson,Olajide Abiola,Kenneth Aldape,Kristin Alfaro,Donát Alpár,Donát Alpár,Samirkumar B. Amin,David M. Ashley,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Jill S. Barnholtz-Sloan,Rameen Beroukhim,Rameen Beroukhim,Christoph Bock,Christoph Bock,Priscilla K. Brastianos,Daniel J. Brat,Andrew R Brodbelt,Alexander F. Bruns,Ketan R. Bulsara,Aruna Chakrabarty,Arnab Chakravarti,Jeffrey H. Chuang,Elizabeth B. Claus,Elizabeth B. Claus,Elizabeth J. Cochran,Jennifer Connelly,Joseph F. Costello,Gaetano Finocchiaro,Michael N. C. Fletcher,Pim J. French,Hui K Gan,Hui K Gan,Mark R. Gilbert,Peter Gould,Matthew R. Grimmer,Antonio Iavarone,Azzam Ismail,Michael D. Jenkinson,Mustafa Khasraw,Hoon Kim,Mathilde C.M. Kouwenhoven,Peter S. LaViolette,Meihong Li,Peter Lichter,Keith L. Ligon,Keith L. Ligon,Allison Lowman,Tathiane M. Malta,Tali Mazor,Kerrie L. McDonald,Annette M. Molinaro,Do-Hyun Nam,Naema Nayyar,Ho Keung Ng,Chew Yee Ngan,Simone P. Niclou,Johanna M. Niers,Houtan Noushmehr,Javad Noorbakhsh,D. Ryan Ormond,Chul-Kee Park,Laila M. Poisson,Raul Rabadan,Raul Rabadan,Bernhard Radlwimmer,Ganesh Rao,Guido Reifenberger,Jason K. Sa,Michael Schuster,Brian L. Shaw,Susan C Short,Peter A. E. Sillevis Smitt,Andrew E. Sloan,Andrew E. Sloan,Marion Smits,Hiromichi Suzuki,Ghazaleh Tabatabai,Erwin G. Van Meir,Colin Watts,Michael Weller,Pieter Wesseling,Bart A. Westerman,Georg Widhalm,Adelheid Woehrer,W. K. Alfred Yung,Gelareh Zadeh,Jason T. Huse,John de Groot,Lucy F. Stead,Roel G.W. Verhaak +96 more
TL;DR: The results suggest that the strongest selective pressures occur during early glioma development and that current therapies shape this evolution in a largely stochastic manner.
Journal ArticleDOI
Immunoregulatory functions of VISTA.
Elizabeth C. Nowak,J. Louise Lines,Frederick S. Varn,Jie Deng,Aurelien Sarde,Rodwell Mabaera,Anna Kuta,Isabelle Le Mercier,Chao Cheng,Randolph J. Noelle +9 more
TL;DR: The functions of this molecule are described in the context of cancer immunotherapy and factors that may influence the use of anti‐VISTA antibody in combination therapy and how genomic analysis may assist in providing indications for treatment are discussed.
Journal ArticleDOI
Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment
TL;DR: In multiple tumor types, it was found that the protective effect of CD8+ T cell infiltration was heavily modulated by coinfiltration of macrophages and other myeloid cell types, suggesting the involvement of myeloids-derived suppressor cells in tumor development.
Journal ArticleDOI
Hypoxia-Induced VISTA Promotes the Suppressive Function of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
Jie Deng,Jiannan Li,Aurelien Sarde,J. Louise Lines,Yu-Chi Lee,David C. Qian,Dov A. Pechenick,Richard Manivanh,Isabelle Le Mercier,Christopher H. Lowrey,Frederick S. Varn,Chao Cheng,David A. Leib,Randolph J. Noelle,Rodwell Mabaera +14 more
TL;DR: It is shown that VISTA and HIF1α activity are correlated in a cohort of colorectal cancer patients and that targeting VISTA may mitigate the deleterious effects of hypoxia on antitumor immunity.
Journal ArticleDOI
Glioma progression is shaped by genetic evolution and microenvironment interactions
Frederick S. Varn,Kevin M. Johnson,Jan Martinek,Jason T. Huse,MacLean Nasrallah,Pieter Wesseling,Lee Cooper,Tathiane M. Malta,Taylor Wade,Thais S. Sabedot,Daniel J. Brat,Peter Gould,Adelheid Wöehrer,Kenneth Aldape,Azzam Ismail,Santhosh Sivajothi,Floris P. Barthel,Hoon-Kyo Kim,Emre Kocakavuk,Nazia Ahmed,Kieron White,Indrani Datta,Hyo Eun Moon,Steven Pollock,Christine N. Goldfarb,Ga Hyun Lee,Luciano Garofano,Kevin W. Anderson,Djamel Nehar-Belaid,Jill S. Barnholtz-Sloan,Spyridon Bakas,Annette T. Byrne,Fulvio D'Angelo,Hui K Gan,Mustafa Khasraw,Simona Migliozzi,D. Ryan Ormond,Sun Ha Paek,Erwin G. Van Meir,Annemiek M E Walenkamp,Colin Watts,Tobias Weiss,Michael Weller,A. Karolina Palucka,Lucy F. Stead,Laila M. Poisson,Houtan Noushmehr,Antonio Iavarone,Roel G.W. Verhaak,Kristin Alfaro,Samirkumar B. Amin,David M. Ashley,Christoph Bock,Andrew Brodbelt,Ketan R. Bulsara,Ana Valeria B Castro,Jennifer Connelly,Joseph F. Costello,John de Groot,G. Finocchiaro,Pim J. French,Anna Golebiewska,Annika Hau,Chibo Hong,Craig Horbinski,Kasthuri Kannan,Mathilde C.M. Kouwenhoven,Anna Lasorella,Peter S. LaViolette,Keith L. Ligon,Allison Lowman,Shwetal Vatsal Mehta,Hrvoje Miletic,Annette M. Molinaro,Ho Keung Ng,Simone P. Niclou,Johanna M. Niers,T. J. Phillips,Raul Rabadan,Ganesh Rao,Guido Reifenberger,Nader Sanai,Susan C Short,Peter A. E. Sillevis Smitt,Andrew E. Sloan,Marion Smits,James M. Snyder,Hiromichi Suzuki,Ghazaleh Tabatabai,Georgette Tanner,William H. Tomaszewski,Michael J. Wells,Bart A. Westerman,Helen Wheeler,Jichun Xie,W. K. Alfred Yung,Gelareh Zadeh,Junfei Zhao +97 more
TL;DR: In this paper , RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma were analyzed.