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Xiang Zhou
Researcher at University of Michigan
Publications - 172
Citations - 20187
Xiang Zhou is an academic researcher from University of Michigan. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 33, co-authored 133 publications receiving 16025 citations. Previous affiliations of Xiang Zhou include Duke University & University of Chicago.
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Journal ArticleDOI
Statistical analysis of spatial expression patterns for spatially resolved transcriptomic studies
TL;DR: Analyzing four published spatially resolved transcriptomic datasets using SPARK shows it can be up to ten times more powerful than existing methods and disclose biological discoveries that otherwise cannot be revealed by existing approaches.
Journal ArticleDOI
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway
Xiang Zhou,Liangli Wang,Hiroshi Hasegawa,Priyanka Amin,Bao Xia Han,Shinjiro Kaneko,You-Wen He,Fan Wang +7 more
TL;DR: These studies represent in vivo characterization of PIK3C3 functions in mammals and provide insights into the complexity of neuronal endo-lysosomal and autophagic pathways.
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A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics
Irene Gallego Romero,Bryan J Pavlovic,Irene Hernando-Herraez,Xiang Zhou,Michelle C Ward,Nicholas E. Banovich,Courtney L. Kagan,Jonathan E. Burnett,Constance H. Huang,Amy Mitrano,Claudia Chavarria,Inbar Friedrich Ben-Nun,Yingchun Li,Karen Sabatini,Trevor R. Leonardo,Mana M. Parast,Tomas Marques-Bonet,Louise C. Laurent,Jeanne F. Loring,Yoav Gilad +19 more
TL;DR: A panel of 7 fully characterized chimpanzee induced pluripotent stem cell (iPSC) lines derived from healthy donors is generated, indicating the reprogramming process erases many inter-individual differences.
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Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis
Kelly Devereaux,Claudia Dall'Armi,Abel R. Alcázar-Román,Yuta Ogasawara,Xiang Zhou,Fan Wang,Akitsugu Yamamoto,Pietro De Camilli,Gilbert Di Paolo +8 more
TL;DR: These studies indicate that while Vps34 is the main PI3P source during autophagy, class II PI3Ks also significantly contribute toPI3P generation and regulate AP biogenesis.
Journal ArticleDOI
The genetic architecture of gene expression levels in wild baboons
TL;DR: The results suggest that genes vary in their tolerance of genetic perturbation, and that this property may be conserved across species, and establish the feasibility of eQTL mapping using RNA-seq data alone, and represent an important step towards understanding the genetic architecture of gene expression in primates.