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Xiang Zhou
Researcher at University of Michigan
Publications - 172
Citations - 20187
Xiang Zhou is an academic researcher from University of Michigan. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 33, co-authored 133 publications receiving 16025 citations. Previous affiliations of Xiang Zhou include Duke University & University of Chicago.
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Journal ArticleDOI
Efficient Genome-Wide Sequencing and Low-Coverage Pedigree Analysis from Noninvasively Collected Samples
Noah Snyder-Mackler,William H. Majoros,Michael L. Yuan,Amanda O. Shaver,Jacob B. Gordon,Gisela H. Kopp,Gisela H. Kopp,Gisela H. Kopp,Stephen A. Schlebusch,Jeffrey D. Wall,Susan C. Alberts,Sayan Mukherjee,Xiang Zhou,Jenny Tung +13 more
TL;DR: An optimized laboratory protocol for genome-wide capture of endogenous DNA from noninvasively collected samples, coupled with a novel computational approach to reconstruct pedigree links from the resulting low-coverage data are reported.
Journal ArticleDOI
Accurate and Scalable Construction of Polygenic Scores in Large Biobank Data Sets
Sheng Yang,Sheng Yang,Xiang Zhou +2 more
TL;DR: DBSLMM represents an accurate and scalable method for constructing PGS in biobank scale datasets and achieves scalable and accurate prediction performance across a range of realistic genetic architectures.
Journal ArticleDOI
Epigenetic modifications are associated with inter-species gene expression variation in primates
Xiang Zhou,Xiang Zhou,Carolyn E. Cain,Marsha Myrthil,Noah Lewellen,Noah Lewellen,Katelyn Michelini,Katelyn Michelini,Emily R. Davenport,Matthew Stephens,Jonathan K. Pritchard,Jonathan K. Pritchard,Jonathan K. Pritchard,Yoav Gilad +13 more
TL;DR: Observations suggest that epigenetic modifications are substantially associated with changes in gene expression levels among primates and may represent important molecular mechanisms in primate evolution.
Journal ArticleDOI
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.
Seyedeh M. Zekavat,Seyedeh M. Zekavat,Sanni Ruotsalainen,Robert E. Handsaker,Robert E. Handsaker,Maris Alver,Jonathan M. Bloom,Tim Poterba,Cotton Seed,Jason Ernst,Mark Chaffin,Jesse M. Engreitz,Gina M. Peloso,Ani Manichaikul,Chaojie Yang,Kathleen A. Ryan,Mao Fu,W. Craig Johnson,Michael Y. Tsai,Matthew J. Budoff,Vasan S. Ramachandran,Vasan S. Ramachandran,L. Adrienne Cupples,L. Adrienne Cupples,Jerome I. Rotter,Stephen S. Rich,Wendy S. Post,Braxton D. Mitchell,Adolfo Correa,Andres Metspalu,James G. Wilson,Veikko Salomaa,Manolis Kellis,Manolis Kellis,Mark J. Daly,Benjamin M. Neale,Steven A. McCarroll,Steven A. McCarroll,Ida Surakka,Tõnu Esko,Andrea Ganna,Samuli Ripatti,Samuli Ripatti,Sekar Kathiresan,Sekar Kathiresan,Pradeep Natarajan,Pradeep Natarajan,Namiko Abe,Gonçalo R. Abecasis,Christine M. Albert,Nicholette Palmer Allred,Laura Almasy,Alvaro Alonso,Seth A. Ament,Peter C. Anderson,Pramod Anugu,Deborah Applebaum-Bowden,Dan E. Arking,Donna K. Arnett,Allison E. Ashley-Koch,Stella Aslibekyan,Tim Assimes,Paul L. Auer,Dimitrios Avramopoulos,John Barnard,Kathleen C. Barnes,R. Graham Barr,Emily Barron-Casella,Terri H. Beaty,Diane M. Becker,Lewis C. Becker,Rebecca L. Beer,Ferdouse Begum,Amber L. Beitelshees,Emelia J. Benjamin,Emelia J. Benjamin,Marcos Bezerra,L.F. Bielak,Joshua C. Bis,Thomas W. Blackwell,John Blangero,Eric Boerwinkle,Ingrid B. Borecki,Russell P. Bowler,Jennifer A. Brody,Ulrich Broeckel,Jai G. Broome,Karen Bunting,Esteban G. Burchard,Jonathan Cardwell,Cara L. Carty,Richard Casaburi,James F. Casella,Christy Chang,Daniel I. Chasman,Sameer Chavan,Bo Juen Chen,Wei-Min Chen,Yii-Der Ida Chen,Michael H. Cho,Seung Hoan Choi,Lee-Ming Chuang,Mina K. Chung,Elaine Cornell,Carolyn J. Crandall,James D. Crapo,Joanne E. Curran,Jeffrey L. Curtis,Brian Custer,Coleen M. Damcott,Dawood Darbar,Sayantan Das,Sean P. David,Colleen Davis,Michelle Daya,Mariza de Andrade,Michael R. DeBaun,Ranjan Deka,Dawn L. DeMeo,Scott E. Devine,Ron Do,Qing Duan,Ravi Duggirala,Peter Durda,Susan K. Dutcher,Charles B. Eaton,Lynette Ekunwe,Patrick T. Ellinor,Leslie S. Emery,Charles R. Farber,Leanna Farnam,Tasha E. Fingerlin,Matthew Flickinger,Myriam Fornage,Nora Franceschini,Stephanie M. Fullerton,Lucinda Fulton,Stacey Gabriel,Weiniu Gan,Yan Gao,Margery Gass,Bruce D. Gelb,Xiaoqi Geng,Soren Germer,Christopher R. Gignoux,Mark T. Gladwin,David C. Glahn,Stephanie M. Gogarten,Da Wei Gong,Harald H H Göring,C. Charles Gu,Yue Guan,Xiuqing Guo,Jeffrey Haessler,Michael E. Hall,Daniel N. Harris,Nicola L. Hawley,Jiang He,Ben Heavner,Susan R. Heckbert,Ryan D. Hernandez,David M. Herrington,Craig P. Hersh,Bertha Hidalgo,James E. Hixson,John E. Hokanson,Elliott Hong,Karin F. Hoth,Chao Hsiung,Haley Huston,Chii Min Hwu,Marguerite R. Irvin,Rebecca D. Jackson,Deepti Jain,Cashell E. Jaquish,Min A. Jhun,Jill M. Johnsen,Andrew D. Johnson,Rich Johnston,Kimberly L. Jones,Hyun Min Kang,Robert C. Kaplan,Sharon L.R. Kardia,Laura J. Kaufman,Shannon Kelly,Eimear E. Kenny,Michael D. Kessler,Alyna T. Khan,G.L. Kinney,Barbara A. Konkle,Charles Kooperberg,Holly Kramer,Stephanie Krauter,Christoph Lange,Ethan M. Lange,Leslie A. Lange,Cathy C. Laurie,Cecelia A. Laurie,Meryl S. LeBoff,Seunggeun Lee,Wen Jane Lee,Jonathon LeFaive,David K. Levine,Daniel Levy,Joshua P. Lewis,Yun Li,Honghuang Lin,Keng-Han Lin,Simin Liu,Yongmei Liu,Ruth J. F. Loos,Steven A. Lubitz,Kathryn L. Lunetta,James Luo,Michael C. Mahaney,Barry Make,JoAnn E. Manson,Lauren Margolin,Lisa W. Martin,Susan K. Mathai,Rasika A. Mathias,Patrick F. McArdle,Merry Lynn McDonald,Sean K. McFarland,Stephen T. McGarvey,Hao Mei,Deborah A. Meyers,Julie L. Mikulla,Nancy Min,Mollie A. Minear,Ryan L. Minster,May E. Montasser,Solomon K. Musani,Stanford Mwasongwe,Josyf C. Mychaleckyj,Girish N. Nadkarni,Rakhi P. Naik,Sergei Nekhai,Deborah A. Nickerson,Kari E. North,Jeffrey R. O'Connell,Timothy D. O’Connor,Heather M. Ochs-Balcom,James S. Pankow,George J. Papanicolaou,Margaret G. Parker,Afshin Parsa,Sara Penchev,Juan M. Peralta,Marco V Perez,James A. Perry,Ulrike Peters,Ulrike Peters,Patricia A. Peyser,Larry Phillips,Sam Phillips,Toni I. Pollin,Julia Powers Becker,Meher Preethi Boorgula,Michael Preuss,Dmitry Prokopenko,Bruce M. Psaty,Pankaj Qasba,Dandi Qiao,Zhaohui S. Qin,Nicholas Rafaels,Laura M. Raffield,Dabeeru C. Rao,Laura J. Rasmussen-Torvik,Aakrosh Ratan,Susan Redline,Robert M. Reed,Elizabeth A. Regan,Alexander P. Reiner,Alexander P. Reiner,Kenneth Rice,Dan M. Roden,Carolina Roselli,Ingo Ruczinski,Pamela Russell,Sarah Ruuska,Phuwanat Sakornsakolpat,Shabnam Salimi,Steven L. Salzberg,Kevin Sandow,Vijay G. Sankaran,Christopher Scheller,Ellen M. Schmidt,Karen Schwander,David A. Schwartz,Frank C. Sciurba,Christine E. Seidman,Vivien A. Sheehan,Amol C. Shetty,Aniket Shetty,Wayne Hui Heng Sheu,M. Benjamin Shoemaker,Brian Silver,Edwin K. Silverman,Jennifer A. Smith,Josh Smith,Nicholas L. Smith,Tanja Smith,Sylvia Smoller,Beverly Snively,Tamar Sofer,Nona Sotoodehnia,Adrienne M. Stilp,Elizabeth A. Streeten,Yun Ju Sung,Jody S. Sylvia,Adam A. Szpiro,Carole Sztalryd,Daniel Taliun,Hua Tang,Margaret A. Taub,Kent D. Taylor,Simeon I. Taylor,Marilyn J. Telen,Timothy A. Thornton,Lesley F. Tinker,David L. Tirschwell,Hemant K. Tiwari,Russell P. Tracy,Dhananjay Vaidya,Peter VandeHaar,Scott I. Vrieze,Scott I. Vrieze,Tarik Walker,Robert B. Wallace,Avram D Walts,Emily S. Wan,Fei Fei Wang,Karol E. Watson,Daniel E. Weeks,Bruce S. Weir,Scott T. Weiss,Lu-Chen Weng,Cristen J. Willer,Kayleen Williams,L. Keoki Williams,Carla Wilson,Quenna Wong,Huichun Xu,Lisa R. Yanek,Ivana V. Yang,Rongze Yang,Norann A. Zaghloul,Yingze Zhang,Snow Xueyan Zhao,Wei Zhao,Xiuwen Zheng,Degui Zhi,Xiang Zhou,Michael C. Zody,Sebastian Zoellner +355 more
TL;DR: In this article, the authors used deep-coverage whole genome sequencing in 8392 individuals of European and African ancestry to discover and interpret both single-nucleotide variants and copy number (CN) variation associated with Lp(a).
Journal ArticleDOI
Spatially Informed Cell Type Deconvolution for Spatial Transcriptomics
Ying Ying Ma,Xiang Zhou +1 more
TL;DR: In this paper , a conditional autoregressive-based deconvolution (CARD) method was proposed to combine cell-specific expression information from single-cell RNA sequencing (scRNA-seq) with correlation in cell-type composition across tissue locations.