Xiang Zhou

TL;DR: These findings substantiate the involvement of whisker-derived TGF-β/Smad4 signaling in the formation of the whisker somatotopic maps and show that Smad4-deficient neurons develop simpler terminal arbors and form fewer synapses.

TL;DR: New evidence is provided supporting the causal neuroprotective role of T2D on ALS in the European population and empirically suggestive evidence of increasing risk of T1D onALS in the East Asian population.

TL;DR: An extensive PRS online repository for 35 common cancer traits integrating freely available genome-wide association studies (GWASs) summary statistics from three sources is created, and a framework condenses these summary statistics into PRSs using various approaches such as linkage disequilibrium pruning/p value thresholding and penalized, genome- wide effect size weighting.

TL;DR: The results establish a new set of asthma susceptibility candidate genes that include genes previously implicated in asthma susceptibility as well as novel candidate genes enriched for functions related to T cell receptor signaling and adenosine triphosphate synthesis.

TL;DR: It is shown that PQLseq is the only method currently available that can produce unbiased heritability estimates for sequencing count data and is well suited for differential analysis in large sequencing studies, providing calibrated type I error control and more power compared to the standard linear mixed model methods.