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Xiangrui Meng
Researcher at University of Edinburgh
Publications - 13
Citations - 898
Xiangrui Meng is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Genome-wide association study & Vitamin D and neurology. The author has an hindex of 9, co-authored 13 publications receiving 502 citations. Previous affiliations of Xiangrui Meng include Tsinghua University.
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Journal ArticleDOI
Mapping ICD-10 and ICD-10-CM Codes to Phecodes: Workflow Development and Initial Evaluation
Patrick Wu,Aliya Gifford,Xiangrui Meng,Xue Li,Harry Campbell,Tim Varley,Juan Zhao,Robert J. Carroll,Lisa Bastarache,Joshua C. Denny,Evropi Theodoratou,Wei-Qi Wei +11 more
TL;DR: This study introduces the beta versions of I CD-10 and ICD-10-CM to phecode maps that enable researchers to leverage accumulated ICD/ICD/PheWAS data for PhewAS in the EHR by investigating phenotype reproducibility and conducting a PheW AS.
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Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies
Xue Li,Xiangrui Meng,Maria Timofeeva,Ioanna Tzoulaki,Konstantinos K. Tsilidis,Konstantinos K. Tsilidis,John P. A. Ioannidis,Harry Campbell,Evropi Theodoratou +8 more
TL;DR: Despite a few hundred systematic reviews, meta-analyses, and Mendelian randomisation studies exploring 136 unique health outcomes, convincing evidence of a clear role of SUA level only exists for gout and nephrolithiasis.
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Nature, Nurture, and Cancer Risks: Genetic and Nutritional Contributions to Cancer.
TL;DR: Convincing evidence for association was found only for the intake of alcohol and whole grains in relation to colorectal cancer risk and among the examined gene-diet interactions, only one had moderately strong evidence.
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Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.
Xue Li,Xiangrui Meng,Yazhou He,Athina Spiliopoulou,Maria Timofeeva,Wei-Qi Wei,Aliya Gifford,Tian Yang,Tim Varley,Ioanna Tzoulaki,Ioanna Tzoulaki,Peter K. Joshi,Joshua C. Denny,Paul M. McKeigue,Harry Campbell,Evropi Theodoratou,Evropi Theodoratou +16 more
TL;DR: High serum urate levels were found to be associated with increased risk of different types of cardiac events and may suggest new opportunities and challenges for developing drugs targeting a common mediator that would be beneficial for both the treatment of gout and the prevention of cardiovascular comorbidities.
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Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study.
Yazhou He,Yazhou He,Maria Timofeeva,Susan M. Farrington,P G Vaughan-Shaw,Victoria Svinti,Marion F Walker,Lina Zgaga,Lina Zgaga,Xiangrui Meng,Xue Li,Athina Spiliopoulou,Xia Jiang,Xia Jiang,Elina Hyppönen,Elina Hyppönen,Peter Kraft,Douglas P. Kiel,Douglas P. Kiel,Caroline Hayward,Archie Campbell,David J. Porteous,Katarina Vučić,Iva Kirac,Maša Filipović,Sarah E. Harris,Ian J. Deary,Richard S. Houlston,Ian Tomlinson,Harry Campbell,Evropi Theodoratou,Malcolm G. Dunlop +31 more
TL;DR: Circulating vitamin D may be a CRC biomarker, but a causal effect on CRC risk remains unproven after a large Mendelian randomisation study using an improved genetic instrument for circulating 25-OHD.